Results 11 to 20 of about 51,168 (257)

The pentose phosphate pathway in health and disease. [PDF]

Nat Metab, 2023
The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide phosphate (NADPH). Ribose 5-phosphate is used for nucleotide synthesis, while NADPH is involved in redox homoeostasis as well as in promoting biosynthetic processes, such as the
TeSlaa T, Ralser M, Fan J, Rabinowitz JD.   +3 more
europepmc   +5 more sources

The pentose phosphate pathway and cancer [PDF]

Trends in Biochemical Sciences, 2014
The pentose phosphate pathway (PPP), which branches from glycolysis at the first committed step of glucose metabolism, is required for the synthesis of ribonucleotides and is a major source of NADPH. NADPH is required for and consumed during fatty acid synthesis and the scavenging of reactive oxygen species (ROS).
Krushna C, Patra, Nissim, Hay
openaire   +2 more sources

The in vitro effect of 5-FU and Tamoxifen Chemotherapeutics on penthose phosphate pathway enzymes

Cumhuriyet Science Journal, 2021
The pentose phosphate pathway is the metabolic pathway where NADPH, the reducing force in metabolism, and ribose 5-phosphate, the building block of DNA and RNA, are produced.
Yusuf Temel
doaj   +1 more source

Targeting the Pentose Phosphate Pathway for SARS-CoV-2 Therapy

Metabolites, 2021
SARS-CoV-2 is causing the coronavirus disease 2019 (COVID-19) pandemic, for which effective pharmacological therapies are needed. SARS-CoV-2 induces a shift of the host cell metabolism towards glycolysis, and the glycolysis inhibitor 2-deoxy-d-glucose ...
Denisa Bojkova, Rui Costa, Philipp Reus, Marco Bechtel, Mark-Christian Jaboreck, Ruth Olmer, Ulrich Martin, Sandra Ciesek, Martin Michaelis, Jindrich Cinatl   +9 more
doaj   +1 more source

Transcriptomic profiling sheds light on the blue-light and red-light response of oyster mushroom (Pleurotus ostreatus)

AMB Express, 2020
Blue light is an important environmental factor that induces mushroom primordium differentiation and fruiting body development. Although blue-light treatment has been applied for the production of oyster mushroom (Pleurotus ostreatus), the blue-light ...
Huan Wang, Xidan Tong, Fenghua Tian, Chuanwen Jia, Changtian Li, Yu Li   +5 more
doaj   +1 more source

Metabolic Changes Induced by Deletion of Transcriptional Regulator GCR2 in Xylose-Fermenting Saccharomyces cerevisiae

Microorganisms, 2020
Glucose repression has been extensively studied in Saccharomyces cerevisiae, including the regulatory systems responsible for efficient catabolism of glucose, the preferred carbon source.
Minhye Shin, Soo Rin Kim
doaj   +1 more source

Dual metabolomic profiling uncovers Toxoplasma manipulation of the host metabolome and the discovery of a novel parasite metabolic capability.

PLoS Pathogens, 2020
The obligate intracellular parasite Toxoplasma gondii is auxotrophic for several key metabolites and must scavenge these from the host. It is unclear how T.
William J Olson, Bruno Martorelli Di Genova, Gina Gallego-Lopez, Anthony R Dawson, David Stevenson, Daniel Amador-Noguez, Laura J Knoll   +6 more
doaj   +1 more source

The role of the pentose phosphate pathway on reproductive functions. [PDF]

Anim Reprod
Abstract The application of assisted reproductive techniques (ART) in both farm animals and humans has faced challenges since its inception. Advances in this field have largely depended on a deeper understanding of the metabolic requirements and molecular dynamics of sperm, oocytes, and embryonic development. Glucose, for instance, is commonly utilized
Braga JV, de Camargo J, Marques M, Mondadori RG, Lucia T.   +4 more
europepmc   +4 more sources

Glycolysis and the Pentose Phosphate Pathway Promote LPS-Induced NOX2 Oxidase- and IFN-β-Dependent Inflammation in Macrophages

Antioxidants, 2022
Macrophages undergo a metabolic switch from oxidative phosphorylation to glycolysis when exposed to gram-negative bacterial lipopolysaccharide (LPS), which modulates antibacterial host defence mechanisms.
Jonathan R. Erlich, Eunice E. To, Raymond Luong, Felicia Liong, Stella Liong, Osezua Oseghale, Mark A. Miles, Steven Bozinovski, Robert D. Brooks, Ross Vlahos, Stanley Chan, John J. O’Leary, Doug A. Brooks, Stavros Selemidis   +13 more
doaj   +1 more source

Regulation of the pentose phosphate pathway in cancer [PDF]

Protein & Cell, 2014
Energy metabolism is significantly reprogrammed in many human cancers, and these alterations confer many advantages to cancer cells, including the promotion of biosynthesis, ATP generation, detoxification and support of rapid proliferation. The pentose phosphate pathway (PPP) is a major pathway for glucose catabolism.
Jiang, Peng, Du, Wenjing, Wu, Mian
openaire   +2 more sources