Results 21 to 30 of about 175,216 (165)

Oxidative pentose phosphate pathway and glucose anaplerosis support maintenance of mitochondrial NADPH pool under mitochondrial oxidative stress

Bioengineering & Translational Medicine, 2020
Mitochondrial NADPH protects cells against mitochondrial oxidative stress by serving as an electron donor to antioxidant defense systems. However, due to technical challenges, it still remains unknown as to the pool size of mitochondrial NADPH, its ...
Sun Jin Moon, Wentao Dong, Gregory N. Stephanopoulos, Hadley D. Sikes   +3 more
doaj   +1 more source

The Glucose-Glutamine Metabolic Interplay in MCF-7 Cells, a Hormone-Sensitive Breast Cancer Model

Frontiers in Bioscience-Landmark
Background: Selective deprivation of glutamine has been shown to accelerate the generation of reactive oxygen species (ROS) and to impair the activity of a specific pentose phosphate pathway (PPP) located within the endoplasmic reticulum (ER).
Sonia Carta, Maddalena Ghelardoni, Francesca Vitale, Silvia Ravera, Vanessa Cossu, Nadia Bertola, Serena Losacco, Jonathan Martinelli, Edoardo Dighero, Mattia Riondato, Anna Maria Orengo, Matteo Bauckneht, Sabrina Chiesa, Gianmario Sambuceti, Cecilia Marini   +14 more
doaj   +1 more source

Application of different methods used to transfect small molecule NADPH into cells [PDF]

Jichu yixue yu linchuang
Objective To compare the three different methods for direct transfection of small exogenous nicotinamide adenine dinucleotide phosphate(NADPH) into cells by a non-metabolic pathway.
LI Haoyue, DU Wenjing, LI Wei
doaj   +1 more source

The Ca2+-Regulation of the Mitochondrial External NADPH Dehydrogenase in Plants Is Controlled by Cytosolic pH. [PDF]

PLoS ONE, 2015
NADPH is a key reductant carrier that maintains internal redox and antioxidant status, and that links biosynthetic, catabolic and signalling pathways.
Meng-Shu Hao, Anna M Jensen, Ann-Sofie Boquist, Yun-Jun Liu, Allan G Rasmusson   +4 more
doaj   +1 more source

A comparative transcriptomic, fluxomic and metabolomic analysis of the response of Saccharomyces cerevisiae to increases in NADPH oxidation

BMC Genomics, 2012
Background Redox homeostasis is essential to sustain metabolism and growth. We recently reported that yeast cells meet a gradual increase in imposed NADPH demand by progressively increasing flux through the pentose phosphate (PP) and acetate pathways and
Celton Magalie, Sanchez Isabelle, Goelzer Anne, Fromion Vincent, Camarasa Carole, Dequin Sylvie   +5 more
doaj   +1 more source

NAD- and NADPH-Contributing Enzymes as Therapeutic Targets in Cancer: An Overview

Biomolecules, 2020
Actively proliferating cancer cells require sufficient amount of NADH and NADPH for biogenesis and to protect cells from the detrimental effect of reactive oxygen species.
Alvinsyah Adhityo Pramono, Gulam M. Rather, Herry Herman, Keri Lestari, Joseph R. Bertino   +4 more
doaj   +1 more source

A novel flow cytometry assay using dihydroethidium as redox-sensitive probe reveals NADPH oxidase-dependent generation of superoxide anion in human platelets exposed to amyloid peptide β

Platelets, 2019
Reactive oxygen species (ROS) generation is critical in the regulation of platelets, which has important implications in the modulation of hemostasis and thrombosis. Nonetheless, despite several assays have been described and successfully utilized in the
Aisha Alsheikh Abubaker, Dina Vara, Ian Eggleston, Ilaria Canobbio, Giordano Pula   +4 more
doaj   +1 more source

Real Time Monitoring of NADPH Concentrations in Corynebacterium glutamicum and Escherichia coli via the Genetically Encoded Sensor mBFP

Frontiers in Microbiology, 2018
Analyses of intracellular NADPH concentrations are prerequisites for the design of microbial production strains and process optimization. mBFP was described as metagenomics derived, blue fluorescent protein showing NADPH-dependent fluorescence ...
Oliver Goldbeck, Alexander W. Eck, Gerd M. Seibold, Gerd M. Seibold   +3 more
doaj   +1 more source

Nitric Oxide-Induced Polycystic Ovaries in The Wistar Rat [PDF]

International Journal of Fertility and Sterility, 2012
Background Nitric oxide (NO) involves in polycystic ovary syndrome (PCOS), a cause of infertility in women during the reproductive age. The PCOS is now categorized as an inflammatory phenomenon.
Fatemeh Hassani, Manizheh Karami, Ph.D. 1 1, Mohammad Reza Jalali Nadoushan, Poopak Eftekhari Yazdi   +4 more
doaj  

Pharmacological and genetic inhibition of NADPH oxidase does not reduce brain damage in different models of perinatal brain injury in newborn mice

Neurobiology of Disease, 2008
Background: Inflammation and reactive oxygen species (ROS) are important in the development of perinatal brain injury. The ROS-generating enzyme NADPH oxidase (Nox2) is present in inflammatory cells and contributes to brain injury in adult animal models.
Christina Doverhag, Matthias Keller, Anna Karlsson, Maj Hedtjarn, Ulf Nilsson, Edith Kapeller, Gergely Sarkozy, Lars Klimaschewski, Christian Humpel, Henrik Hagberg, Georg Simbruner, Pierre Gressens, Karin Savman   +12 more
doaj   +1 more source