Results 41 to 50 of about 175,216 (165)

Adrenergic, nitrergic and peptidergic innervation of the urethral muscle in the boar.

Folia Histochemica et Cytobiologica, 2004
In this study, the innervation of the urethral muscle in adult male pigs was investigated using combined NADPH-diaphorase (NADPH-d) histochemistry and immunocytochemistry. Nerve fibres supplying the urethral muscle were found to show NADPH-d activity and
Mirosław Lakomy, Krzysztof Czaja, Jerzy Kaleczyc, Waldemar Sienkiewicz   +3 more
doaj   +1 more source

Spectrophotometric assays for measuring redox biomarkers in blood and tissues: the NADPH network

Redox Report, 2018
Nicotinamide adenine dinucleotide (NAD+/NADH) along with its phosphorylated form (NADP+/NADPH) are two molecules ubiquitously present in all organisms, and they play key roles as cofactors in fundamental catabolic and anabolic processes, respectively ...
Aristidis S. Veskoukis, Nikos V. Margaritelis, Antonios Kyparos, Vassilis Paschalis, Michalis G. Nikolaidis   +4 more
doaj   +1 more source

NADPH oxidase is involved in regulation of gene expression and ROS overproduction in soybean (Glycine max L.) seedlings exposed to cadmium

Acta Societatis Botanicorum Poloniae, 2017
Cadmium-induced oxidative burst is partially mediated by NADPH oxidase. The aim of the present research was to evaluate the role of NADPH oxidase in soybeans’ response to short-term cadmium stress.
Jagna Chmielowska-Bąk, Magdalena Arasimowicz-Jelonek, Karolina Izbiańska, Marina Frontasyeva, Inga Zinicovscaia, Carolina Guiance-Varela, Joanna Deckert   +6 more
doaj   +1 more source

A role for NADPH oxidase in antigen presentation

Frontiers in Immunology, 2013
The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expressed in phagocytes is a multi-subunit enzyme complex that generates superoxide (O2.-).
Gail J Gardiner, Sarah N Deffit, Shawna eMcLetchie, Liliana ePérez, Crystal C Walline, Janice S Blum   +5 more
doaj   +1 more source

Consumption of NADPH for 2-HG Synthesis Increases Pentose Phosphate Pathway Flux and Sensitizes Cells to Oxidative Stress

Cell Reports, 2018
Summary: Gain-of-function mutations in isocitrate dehydrogenase 1 (IDH1) occur in multiple types of human cancer. Here, we show that these mutations significantly disrupt NADPH homeostasis by consuming NADPH for 2-hydroxyglutarate (2-HG) synthesis. Cells
Susan J. Gelman, Fuad Naser, Nathaniel G. Mahieu, Lisa D. McKenzie, Gavin P. Dunn, Milan G. Chheda, Gary J. Patti   +6 more
doaj   +1 more source

Measuring the rate of NADPH consumption by glutathione reductase in the cytosol and mitochondria.

PLoS ONE
BackgroundNADPH is an essential co-factor supporting the function of enzymes that participate in both inflammatory and anti-inflammatory pathways in myeloid cells, particularly macrophages.
Kenneth K Y Ting, Eric Floro, Riley Dow, Jenny Jongstra-Bilen, Myron I Cybulsky, Jonathan V Rocheleau   +5 more
doaj   +1 more source

Crosstalk between HDAC6 and Nox2-based NADPH oxidase mediates HIV-1 Tat-induced pro-inflammatory responses in astrocytes

Redox Biology, 2017
Histone deacetylase 6 (HDAC6) likely is important in inflammatory diseases. However, how HDAC6 exerts its effect on inflammatory processes remains unclear.
Gi Soo Youn, Hyundong Cho, Donggyu Kim, Soo Young Choi, Jinseu Park   +4 more
doaj   +1 more source

Mechanisms of Activation of NADPH Oxidases

Japanese Journal of Infectious Diseases, 2004
The members of the NOX family of enzymes are expressed in a variety of tissues and serve a number of functions. There is a high level of conservation of primary protein sequence, as well as functional features, although specialized responses are beginning to emerge.
Clark, Robert A., Epperson, Terry Kay, Valente, Anthony J.   +2 more
openaire   +2 more sources

Regulation of FSP1 myristoylation by NADPH: A novel mechanism for ferroptosis inhibition

Redox Biology
Excitotoxicity is a prevalent pathological event in neurodegenerative diseases. The involvement of ferroptosis in the pathogenesis of excitotoxicity remains elusive.
Na Liu, Wei-Long Wu, Xiao-Rui Wan, Jing Wang, Jia-Ni Huang, Yi-Yue Jiang, Yi-Chao Sheng, Jun-Chao Wu, Zhong-Qin Liang, Zheng-Hong Qin, Yan Wang   +10 more
doaj   +1 more source

Long non-coding RNA LINC01532 sustains redox homeostasis and accelerates lenvatinib resistance in hepatocellular carcinoma

Journal of Advanced Research
Introduction: Lenvatinib is the first-line therapy of hepatocellular carcinoma (HCC) and the high frequency of lenvatinib resistance hinders the improvement of HCC treatment. Since NADPH plays vital roles in antioxidant defense and reductive biosynthesis,
Yang Hu, Muhua Chen, Shiqi Sun, Chunfeng Zhang, Zechang Xin, Xiaoyan Sun, Kun Wang, Kemin Jin, Xiaojuan Du, Baocai Xing, Xiaofeng Liu   +10 more
doaj   +1 more source