Results 161 to 170 of about 95,385 (310)

Research progress of neurovascular units involved in ischemic stroke

Ibrain, EarlyView.
The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang, Hao Tong, Zhuo‐Fan Ye, Zu‐Cai Xu, Tao Tao   +4 more
wiley   +1 more source

Targeting NADPH oxidase-driven oxidative stress in diabetic cardiomyopathy: mechanisms and therapeutic perspectives. [PDF]

Front Pharmacol
Ye Z, Wang S, Wan Z, Huang B, Guo J.
europepmc   +1 more source

In vitro Activation of the NADPH Oxidase by Fluoride [PDF]

, 1996
Jutta Wölfl, Marie‐Claire Dagher, Alexandra Fuchs, Miklós Geiszt, Erzsébet Ligeti   +4 more
openalex   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

From multi‐omics to precision medicine in intracranial aneurysm: Biomarker discovery and multimodal integration

Interdisciplinary Medicine, EarlyView.
This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang, Yufei Yang, Bingxu Chen, Yanmeng Zhao, Haitao Sun   +4 more
wiley   +1 more source

Enhancing Selectivity and Potency of S_NAr Covalent Inhibitors of NADPH Oxidase Enzymes. [PDF]

J Med Chem
Ogboo BC, Patel KB, Massari M, Marchese S, Reis J, Joyce EJ, Lin MJ, Rabb JD, Abidakun OA, Lin Q, van der Vliet A, Mattevi A, Heppner DE.   +12 more
europepmc   +1 more source

Stabilization of human neutrophil NADPH oxidase activated in a cell-free system by cytosolic proteins and by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide.

, 1992
Minoru Tamura, M Takeshita, J T Curnutte, David J. Uhlinger, J. David Lambeth   +4 more
openalex   +1 more source

Cell Apoptosis and Glucocorticoid‐Induced Osteonecrosis

Med Research, EarlyView.
The review identifies glucocorticoid‐induced osteocyte/osteoblast apoptosis as central to femoral head osteonecrosis (GION), mediated through STAT1‐caspase‐3, PI3K/Akt, Wnt/β‐catenin, and oxidative stress pathways. Emerging therapies targeting these pathways (e.g., HIF‐1α stabilization, AMPK activation, and exosome‐mediated miRNA delivery) show ...
Xiumei Tang, Yanyun Pang, Peijia Zhu, Zhengdong Zhang, Sen Guo, Zhijian Wei, Wenzhao Wang, Bin Ning   +7 more
wiley   +1 more source

p47phox: A Central Regulator of NADPH Oxidase Function and a Promising Therapeutic Target in Redox-Related Diseases. [PDF]

Cells
Gamble ME, Sureshkumar S, Carrera Espinoza MJ, Hakim NL, Espitia CM, Bi F, Kelly KR, Wang W, Nawrocki ST, Carew JS.   +9 more
europepmc   +1 more source

Activation of NADPH oxidase in human neutrophils permeabilized with Staphylococcus aureus alpha-toxin. A lower Km when the enzyme is activated in situ.

, 1992
Sue A. Bauldry, V N Nasrallah, David Bass   +2 more
openalex   +1 more source