Results 221 to 230 of about 424,484 (404)

Therapeutic potential of hesperidin in diabetes mellitus‐induced erectile dysfunction through Nrf2‐mediated ferroptosis and oxidative stress

Andrology, EarlyView.
Abstract Background Among erectile dysfunction (ED) caused by metabolic abnormalities, diabetes mellitus‐induced ED (DMED) progresses rapidly, manifests with severe symptoms, and shows reduced responsiveness to conventional medications. Hyperglycemia in the corpus cavernosum has been linked to the induction of both ferroptosis and oxidative stress ...
Sheng Xin, Wen Song, Jiaquan Mao, Peng Hu, Zhong Chen, Jihong Liu, Xiaodong Song, Qian Fang, Kai Cui   +8 more
wiley   +1 more source

Therapeutic potential of NADPH oxidase 1/4 inhibitors

British Journal of Pharmacology, 2017
G. Teixeira, C. Szyndralewiez, S. Molango, S. Carnésecchi, F. Heitz, P. Wiesel, J. M. Wood   +6 more
semanticscholar   +1 more source

Relaxin‐2 improves type I diabetes mellitus‐induced erectile dysfunction in rats by protecting cavernous endothelial and smooth muscle function, and inhibiting penile fibrosis and apoptosis

Andrology, EarlyView.
Abstract Background Diabetes mellitus‐induced erectile dysfunction (DMED) responds poorly to first‐line treatments, necessitating the development of new therapeutic strategies. Relaxin‐2 (RLX‐2) plays a crucial role in protecting vascular endothelium, vasodilatation, and antifibrosis in various diseases.
Bocheng Tu, Kang Liu, Bo Wen, Peng Hu, Taotao Sun, Beining Li, Manan Sulaiman, Shujun Jiang, Tao Wang, Jihong Liu, Yang Luan   +10 more
wiley   +1 more source

Effect of NADPH oxidase inhibition on endothelial cell ELAM-1 mRNA expression

, 1992
Yukio Suzuki, Weizheng Wang, Thanh Vu, Thomas A. Raffin   +3 more
openalex   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.

, 1994
Hidetoshi Sumimoto, Yohko Kage, Hiroyuki Nunoi, Hiroyuki Sasaki, Takeru Nose, Yasuyuki Fukumaki, M. Ohno, S Minakami, Koichiro Takeshige   +8 more
openalex   +1 more source

Spermine suppresses the activation of human neutrophil NADPH oxidase in cell-free and semi-recombinant systems [PDF]

, 1996
Kenichi Ogata, Naoya NISHIMOTO, David J. Uhlinger, Kazuei Igarashi, Masazumi Takeshita, Minoru Tamura   +5 more
openalex   +1 more source

A Plant Homolog of the Neutrophil NADPH Oxidase gp91^phox Subunit Gene Encodes a Plasma Membrane Protein with Ca²⁺ Binding Motifs [PDF]

, 1998
T.C. Stevenson Keller, Howard G. Damude, Dietrich Werner, Peter Doerner, Richard A. Dixon, Chris Lamb   +5 more
openalex   +1 more source

Vitamin D deficiency induces erectile dysfunction: Role of superoxide and Slpi

British Journal of Pharmacology, EarlyView.
Background and Purpose Epidemiological studies suggest a relationship between vitamin D deficiency and erectile dysfunction (ED). We hypothesized that vitamin D deficiency or vitamin D receptor (VDR) knockout causes ED and analysed the underlying molecular mechanisms.
Miguel A. Olivencia, Belén Climent, Bianca Barreira, Daniel Morales‐Cano, Ana Sánchez, Argentina Fernández, Borja García‐Gómez, Javier Romero‐Otero, Claudia Rodríguez, Laura Moreno, Dolores Prieto, María Jesús Larriba, Angel Cogolludo, Javier Angulo, Francisco Perez‐Vizcaino   +14 more
wiley   +1 more source

Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3‐kinases: Binding partners of SH3 domains? [PDF]

, 1996
Chris P. Ponting
openalex   +1 more source