Results 31 to 40 of about 30,089 (299)

NADPH Oxidase and Cardiac Failure [PDF]

Journal of Cardiovascular Translational Research, 2010
Increases in oxidative stress in the heart play an important role in mediating hypertrophy, apoptosis, fibrosis, mitochondrial dysfunction, and the consequent development of heart failure. Although it has been widely believed that electron leakage from the mitochondrial electron transport chain is the primary source of oxidative stress in the failing ...
Junichi Sadoshima, Junya Kuroda
openaire   +3 more sources

Defects in Nicotinamide-adenine Dinucleotide Phosphate Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel DiseaseSummary

Cellular and Molecular Gastroenterology and Hepatology, 2015
Background & Aims: Defects in intestinal innate defense systems predispose patients to inflammatory bowel disease (IBD). Reactive oxygen species (ROS) generated by nicotinamide-adenine dinucleotide phosphate (NADPH) oxidases in the mucosal barrier ...
Patti Hayes, Sandeep Dhillon, Kim O’Neill, Cornelia Thoeni, Ken Y. Hui, Abdul Elkadri, Conghui H. Guo, Lidija Kovacic, Gabriella Aviello, Luis A. Alvarez, Anne M. Griffiths, Scott B. Snapper, Steven R. Brant, James H. Doroshow, Mark S. Silverberg, Inga Peter, Dermot P.B. McGovern, Judy Cho, John H. Brumell, Holm H. Uhlig, Billy Bourke, Aleixo M. Muise, Ulla G. Knaus   +22 more
doaj   +1 more source

NADPH Oxidases: Progress and Opportunities [PDF]

Antioxidants & Redox Signaling, 2014
From the initial discovery in 1999 that NADPH oxidases comprise a family of enzymes to our current focus on drug development to treat multiple pathologies related to this enzyme family, progress has been swift and impressive. We have expanded our understanding of the extent of the family, the basic enzymatic biochemistry, the multiple cellular ...
K GriendlingKathy, San MartinAlejandra
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

NADPH Oxidases, Angiogenesis, and Peripheral Artery Disease

Antioxidants, 2017
Peripheral artery disease (PAD) is caused by narrowing of arteries in the limbs, normally occurring in the lower extremities, with severe cases resulting in amputation of the foot or leg.
Pradeep Manuneedhi Cholan, Siân P. Cartland, Mary M. Kavurma   +2 more
doaj   +1 more source

Structures of human dual oxidase 1 complex in low-calcium and high-calcium states

Nature Communications, 2021
Dual oxidases (DUOXs), assembled from the catalytic DUOX and the auxiliary DUOXA subunits, produce hydrogen peroxide by transferring electrons from intracellular NADPH to extracellular oxygen in a calcium-activated manner. Here authors report the cryo-EM
Jing-Xiang Wu, Rui Liu, Kangcheng Song, Lei Chen   +3 more
doaj   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

NADPH Oxidase Deficiency: A Multisystem Approach [PDF]

Oxidative Medicine and Cellular Longevity, 2017
The immune system is a complex system able to recognize a wide variety of host agents, through different biological processes. For example, controlled changes in the redox state are able to start different pathways in immune cells and are involved in the killing of microbes.
Giuliana Giardino, Maria Pia Cicalese, Ottavia Delmonte, Maddalena Migliavacca, Boaz Palterer, Lorenzo Loffredo, Emilia Cirillo, Vera Gallo, Francesco Violi, Claudio Pignata   +9 more
openaire   +4 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Redox Signaling of NADPH Oxidases Regulates Oxidative Stress Responses, Immunity and Aging

Antioxidants, 2018
An accumulating body of evidence suggests that transient or physiological reactive oxygen species (ROS) generated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidases act as a redox signal to re-establish homeostasis.
Collin Y. Ewald
doaj   +1 more source