Results 51 to 60 of about 25,108 (267)

Targeting NADPH oxidases in vascular pharmacology

, 2012
Oxidative stress is a molecular dysregulation in reactive oxygen species (ROS) metabolism, which plays a key role in the pathogenesis of atherosclerosis, vascular inflammation and endothelial dysfunction. It is characterized by a loss of nitric oxide (NO)
Matusik, Paweł, Schramm, Agata, Guzik, Tomasz J., Osmenda, Grzegorz   +3 more
core   +1 more source

NADPH Oxidases: Progress and Opportunities [PDF]

Antioxidants & Redox Signaling, 2014
From the initial discovery in 1999 that NADPH oxidases comprise a family of enzymes to our current focus on drug development to treat multiple pathologies related to this enzyme family, progress has been swift and impressive. We have expanded our understanding of the extent of the family, the basic enzymatic biochemistry, the ...
Alejandra, San Martin, Kathy K, Griendling   +1 more
openaire   +2 more sources

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Peroxidasin-mediated crosslinking of collagen IV is independent of NADPH oxidases

Redox Biology, 2018
Collagen IV is a major component of the basement membrane in epithelial tissues. The NC1 domains of collagen IV protomers are covalently linked together through sulfilimine bonds, the formation of which is catalyzed by peroxidasin.
Gábor Sirokmány, Hajnal A. Kovács, Enikő Lázár, Krisztina Kónya, Ágnes Donkó, Balázs Enyedi, Helmut Grasberger, Miklós Geiszt   +7 more
doaj   +1 more source

VEO-IBD NOX1 variant highlights a structural region essential for NOX/DUOX catalytic activity

Redox Biology, 2023
Inflammatory bowel diseases (IBD) are chronic intestinal disorders that result from an inappropriate inflammatory response to the microbiota in genetically susceptible individuals, often triggered by environmental stressors.
Josie Ward, Suisheng Zhang, Adam Sikora, Radoslaw Michalski, Yuting Yin, Aurora D'Alessio, Rachel M. McLoughlin, Vincent Jaquet, Franck Fieschi, Ulla G. Knaus   +9 more
doaj   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy

Respiratory Research, 2005
Background The sources and measurement of reactive oxygen species (ROS) in intact organs are largely unresolved. This may be related to methodological problems associated with the techniques currently employed for ROS detection.
Schudt Christian, Schermuly Ralph T, Ghofrani Hossein A, Schütte Hartwig, Schäfer Rolf U, Tiyerili Vedat, Fuchs Beate, Kuzkaya Nermin, Weissmann Norbert, Sydykov Akylbek, Egemnazarow Bakytbek, Seeger Werner, Grimminger Friedrich   +12 more
doaj   +1 more source

Recent Developments in the Probes and Assays for Measurement of the Activity of NADPH Oxidases

, 2017
International audienceNADPH oxidases are a family of enzymes capable of transferring electrons from NADPH to molecular oxygen. A major function of NADPH oxidases is the activation of molecular oxygen into reactive oxygen species.
Zielonka, Jacek, Hardy, Micael, Michalski, Radoslaw, Balaraman Kalyanaraman, Micael Hardy, Gang Cheng, Radosław Michalski, Adam Sikora, Podsiadly, Radoslaw, Kalyanaraman, Balaraman, Radosław Podsiadły, Cheng, Gang, Sikora, Adam, Zielonka, Monika, Monika Zielonka, Ouari, Olivier, Jacek Zielonka, Olivier Ouari   +17 more
core   +1 more source