Results 61 to 70 of about 42,623 (284)

Functional Interplay Between Arabidopsis NADPH Oxidases and Heterotrimeric G Protein

Molecular Plant-Microbe Interactions, 2013
The plant NADPH oxidases produce reactive oxygen species (ROS) in response to pathogens that have diverse functions in different cellular contexts. Distinct phenotypic outcomes may derive from the interaction of NADPH oxidase-dependent ROS with other ...
Miguel Angel Torres, Jorge Morales, Clara Sánchez-Rodríguez, Antonio Molina, Jeffery L. Dangl   +4 more
doaj   +1 more source

LPS-induced Pellino3 degradation is mediated by p62-dependent autophagy [PDF]

, 2012
Background: In macrophages Toll-like receptor 4 (TLR4) is activated in response to lipopolysaccharide (LPS) and induces proinflammatory cytokine expression. Therefore, mechanisms terminating proinflammatory gene expression are important.
Brüne, Bernhard, Eifler, Lisa, Heeg, Annika, Heide, Hermann, Knape, Tilo, Knethen, Andreas von, Kuchler, Laura   +6 more
core   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Airborne 1O2 Delivery via a Superhydrophobic Dressing as a Pathway to Next‐Generation Wound Therapies, an in Vivo Murine Burn Model Study

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the SH bandage placed on an infected burn wound and its role in wound healing. A superhydrophobic PDMS membrane coated with the PS verteporfin is placed over the wound area and illuminated with a red laser at 690 nm, generating airborne 1O2 above the tissue.
Fernanda Viana Cabral, QianFeng Xu, Natalie Eidenschink, Pareesha Haresh, Alessandra Nara de Souza Rastelli, Jeremy Goverman, Alexander Greer, Alan M. Lyons, Tayyaba Hasan   +8 more
wiley   +1 more source

Mitochondrial regulation of NADPH oxidase in hindlimb unweighting rat cerebral arteries.

PLoS ONE, 2014
Exposure to microgravity results in post-flight cardiovascular deconditioning and orthostatic intolerance in astronauts. Vascular oxidative stress injury and mitochondrial dysfunction have been indicated in this process.
Ran Zhang, Hai-hong Ran, Liang Peng, Fei Xu, Jun-fang Sun, Lan-ning Zhang, Yong-yan Fan, Li Peng, Geng Cui   +8 more
doaj   +1 more source

Reactive oxygen species generated in chloroplasts contribute to tobacco leaf infection by the necrotrophic fungus Botrytis cinerea [PDF]

, 2017
Reactive oxygen species (ROS) play fundamental roles in plant responses to pathogen infection, including modulation of cell death processes and defense-related gene expression.
Bisaro, Fabiana, Carrillo, Nestor Jose, Krapp, Adriana del Rosario, Maiale, Santiago Javier, Pieckenstain, Fernando Luis, Rossi, Franco Rubén   +5 more
core   +1 more source

Hierarchically Engineered Multi‐Enzyme Nanoreactors for in vitro Drug Biosynthesis and Pathway Transplantation Into Cells

Advanced Materials, EarlyView.
A hierarchically structured metal–organic framework (eMIL) is shown to host the complete six‐enzyme biosynthesis pathway for the anti‐cancer pigment violacein, reshaping reaction dynamics and multiplying in vitro yields. eMIL nanoreactors deliver this reconstituted bacterial multi‐protein system into mammalian cells, where cell‐derived substrates and ...
Ainur Sharip, Somayah S. Qutub, Manar M. Farooqui, Walaa Baslyman, Nida Khalfay, Lukman O. Alimi, Patricia Lopez Sanchez, Lingyun Zhao, Milena Chernyshevskaia, Giovanni Colombo, Niveen M. Khashab, Stefan T. Arold, Raik Grünberg   +12 more
wiley   +1 more source

Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy

Respiratory Research, 2005
Background The sources and measurement of reactive oxygen species (ROS) in intact organs are largely unresolved. This may be related to methodological problems associated with the techniques currently employed for ROS detection.
Schudt Christian, Schermuly Ralph T, Ghofrani Hossein A, Schütte Hartwig, Schäfer Rolf U, Tiyerili Vedat, Fuchs Beate, Kuzkaya Nermin, Weissmann Norbert, Sydykov Akylbek, Egemnazarow Bakytbek, Seeger Werner, Grimminger Friedrich   +12 more
doaj   +1 more source

VEO-IBD NOX1 variant highlights a structural region essential for NOX/DUOX catalytic activity

Redox Biology, 2023
Inflammatory bowel diseases (IBD) are chronic intestinal disorders that result from an inappropriate inflammatory response to the microbiota in genetically susceptible individuals, often triggered by environmental stressors.
Josie Ward, Suisheng Zhang, Adam Sikora, Radoslaw Michalski, Yuting Yin, Aurora D'Alessio, Rachel M. McLoughlin, Vincent Jaquet, Franck Fieschi, Ulla G. Knaus   +9 more
doaj   +1 more source

Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function [PDF]

, 2015
Anthocyanins are reported to have vascular bioactivity, however their mechanisms of action are largely unknown. Evidence suggests that anthocyanins modulate endothelial function, potentially by increasing nitric oxide (NO) synthesis, or enhancing NO ...
Cassidy, Aedin, Czank, Charles, Edwards, Michael, Kay, Colin, Woodward, Gary   +4 more
core   +1 more source