Results 81 to 90 of about 42,623 (284)
Role of NADPH Oxidase in the Endothelial Dysfunction and Oxidative Stress in Aorta of Aged Spontaneous Hypertensive Rats [PDF]
Iranian Journal of Basic Medical Sciences, 2010 Objective(s)Increased reactive oxygen species (ROS) production is implicated in the pathogenesis of arterial hypertension and the development of endothelial dysfunction.
Ashraf Taye, Sven Wind
doaj
Exogenous niacin treatment increases NADPH oxidase in kiwifruit
Brazilian Journal of Biology, 2018 Kiwifruit are a popular fruit worldwide; however, plant growth is threatened by abiotic stresses such as drought and high temperatures. Niacin treatment in plants has been shown to increase NADPH levels, thus enhancing abiotic stresses tolerance.
X. Zhu, L. Pan, T. Xiao, X. Ren, Z. Liu
doaj +1 more source
Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation
Advanced Science, EarlyView.An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng +10 more
wiley +1 more source
Journal of Pharmacological Sciences, 2010 NADPH oxidase is a superoxide (O2−)-generating enzyme first identified in phagocytes that shows bactericidal activities. It has been reported that O2− is also produced in an NADPH-dependent manner in non-phagocytes. In the last decade, non-phagocyte-type
Masato Katsuyama
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NOX Inhibitors - A Promising Avenue for Ischemic Stroke. [PDF]
, 2017 NADPH-oxidase (NOX) mediated superoxide originally found on leukocytes, but now recognized in several types of cells in the brain. It has been shown to play an important role in the progression of stroke and related cerebrovascular disease.
Kim, Jong Youl +3 more
core +1 more source
Drug treatment of hypertension: focus on vascular health [PDF]
, 2016 Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C. +2 more
core +1 more source
Macrophage Extracellular Traps in Immunity and Cancer
Advanced Science, EarlyView.As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li +5 more
wiley +1 more source
Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors. [PDF]
, 2015 Oxidative stress-related diseases underlie many if not all of the major leading causes of death in United States and the Western World. Thus, enormous interest from both academia and pharmaceutical industry has been placed on the development of agents ...
Cifuentes-Pagano, ME +2 more
core +1 more source
Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction
Advanced Science, EarlyView.During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao +8 more
wiley +1 more source
Vascular NADPH Oxidases and Atherothrombotic Stroke
StressesOxidative stress constitutes a main molecular mechanism underlying cardiovascular diseases (CVDs). This pathological mechanism can be triggered by NADPH oxidases (NOXs), which produce reactive oxygen species (ROS).
Javier Marqués, Guillermo Zalba
doaj +1 more source