Results 31 to 40 of about 25,108 (267)
NADPH oxidase 4 and its role in the cardiovascular system
Vascular Biology, 2019 The heart relies on complex mechanisms that provide adequate myocardial oxygen supply in order to maintain its contractile function. At the cellular level, oxygen undergoes one electron reduction to superoxide through the action of different types of ...
Stephen P Gray +2 more
doaj +1 more source
Brain Sciences, 2013 Oxidative stress caused by an excess of reactive oxygen species (ROS) is known to contribute to stroke injury, particularly during reperfusion, and antioxidants targeting this process have resulted in improved outcomes experimentally. Unfortunately these
Carli L. Roulston, Sarah K. McCann
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Potential role of NADPH-oxidase in early steps of lead-induced oxidative burst in Vicia faba roots [PDF]
, 2008 The mechanism of oxidative burst induced by lead in Vicia faba excised roots was investigated by luminol-dependent chemiluminescence. Results showed that lead triggered a rapid and dose-dependent increase in chemiluminescence production.
Perchet, Geoffrey-Thibault +7 more
core +1 more source
Effects of Angiotensin II on the Cerebral Circulation: Role of Oxidative Stress
Frontiers in Physiology, 2013 Oxidative stress has emerged as a key component of many diseases that affect the vasculature. Oxidative stress is characterized as a cellular environment where the generation of oxidant molecules overwhelms endogenous antioxidant defense mechanisms ...
Travice Michael De Silva, Frank eFaraci
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2015 Background & Aims: Defects in intestinal innate defense systems predispose patients to inflammatory bowel disease (IBD). Reactive oxygen species (ROS) generated by nicotinamide-adenine dinucleotide phosphate (NADPH) oxidases in the mucosal barrier ...
Patti Hayes +22 more
doaj +1 more source
Physiological interrelationships between NADPH oxidases and chromatin remodelling
, 2021 The epigenetic landscape describes the chromatin structure of the eukaryotic genome and is therefore the major determinant of gene transcription and hence cellular phenotype.
Brewer, Alison C.; id_orcid +1 more
core +1 more source
NADPH Oxidase and Cardiac Failure [PDF]
Journal of Cardiovascular Translational Research, 2010 Increases in oxidative stress in the heart play an important role in mediating hypertrophy, apoptosis, fibrosis, mitochondrial dysfunction, and the consequent development of heart failure. Although it has been widely believed that electron leakage from the mitochondrial electron transport chain is the primary source of oxidative stress in the failing ...
Junya, Kuroda, Junichi, Sadoshima
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
NADPH Oxidases, Angiogenesis, and Peripheral Artery Disease
Antioxidants, 2017 Peripheral artery disease (PAD) is caused by narrowing of arteries in the limbs, normally occurring in the lower extremities, with severe cases resulting in amputation of the foot or leg.
Pradeep Manuneedhi Cholan +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source