Naegleria fowleri and Naegleria gruberi 20S proteasome: identification and characterization
European Journal of Cell Biology, 2020 The Naegleria are ubiquitous free-living amoebae and are characterized by the presence of three phases in their biological cycle: trophozoite, cyst and flagellate. Of this genus, only Naegleria fowleri has been reported as pathogenic to humans. The proteasome is a multi-catalytic complex and is considered to be the most important structure responsible ...
Angélica Silva-Olivares +5 more
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Cancer Reports, Volume 8, Issue 8, August 2025.ABSTRACT Background The PI3K/Akt/mTOR signaling pathway is commonly deregulated in different types of cancers, contributing to tumor proliferation, persistence, and resistance to treatment. Akt1, a crucial kinase within this pathway, plays a critical role in tumor progression and the occurrence of therapeutic resistance.
Shokoofeh Jamshidi +4 more
wiley +1 more source
Distribution of Naegleria fowleri in Selected Northeast Arkansas Lakes [PDF]
, 1980 Seven northeast Arkansas recreational lakes were examined for the presence of pathogenic and nonpathogenic Naegleria fowleri. Cultural differentiation and microscopic morphology were used as species determining tests, while mouse pathogenicity tests were
Evans, Robert Dean, Hinck, Lawrence W.
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Post-mortem culture of Balamuthia mandrillaris from the brain and cerebrospinal fluid of a case of granulomatous amoebic meningoencephalitis, using human brain microvascular endothelial cells [PDF]
, 2004 The first isolation in the UK of Balamuthia mandrillaris amoebae from a fatal case of granulomatous amoebic meningoencephalitis is reported. Using primary cultures of human brain microvascular endothelial cells (HBMECs), amoebae were isolated from the ...
Alsam +32 more
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Agglutination of Naegleria fowleri by Human Serum
Experimental Biology and Medicine, 1982 AbstractThe capability of 154 serum samples from pediatric outpatients and 101 samples from adults to agglutinate amoebae of Naegleria fowleri nN68 was assessed. Sera from all 19 infants tested had an agglutination titer of 1:4 or less; sera of toddlers had a median agglutination titer of 1:8 and those of adults, 1:16. Only 13 of 154 serum samples from
S. G. Bradley +2 more
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Copper Metabolism in Naegleria gruberi and Its Deadly Relative Naegleria fowleri
Frontiers in Cell and Developmental Biology, 2022 Although copper is an essential nutrient crucial for many biological processes, an excessive concentration can be toxic and lead to cell death. The metabolism of this two-faced metal must be strictly regulated at the cell level. In this study, we investigated copper homeostasis in two related unicellular organisms: nonpathogenic Naegleria gruberi and ...
Ženíšková, Kateřina +2 more
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Luminal Phospholipase D Attacks Bacterial Membranes in Dictyostelium discoideum Phagosomes
Molecular Microbiology, Volume 124, Issue 1, Page 54-65, July 2025.This study shows that PldX, a luminal Phospholipase D, is necessary for the efficient destruction of ingested Klebsiella pneumoniae bacteria in Dictyostelium discoideum phagosomes. PldX and the AlyL lysozyme together attack the bacterial membrane and permeabilize it. To date, the molecular substrate of PldX remains to be determined. ABSTRACT Phagocytic
Otmane Lamrabet +6 more
wiley +1 more source
Primary Amoebic (Naegleria fowleri) Meningoencephalitis Presenting as Status Epilepticus [PDF]
, 2011 Primary amebic meningoencephalitis (PAM) is a rare entity. Usual presenting features are fever, headache and seizures with meningeal signs and this disease carries high mortality rate.
Bharti, V +5 more
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Rare Infectious Diseases: Detection and Clinical Implications
iLABMED, Volume 3, Issue 2, Page 148-157, June 2025.Rare infectious diseases are infections that are uncommon, have a low incidence, and are caused by newly emerging pathogens, cross‐species or ectopic infections, or host immunodeficiencies. The detection and diagnosis of rare infections is one of the main reasons for misdiagnosis and missed diagnosis.
Xin Qian +7 more
wiley +1 more source
A study of various environmental factors on the growth, encystment and survival of free living amoebae : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Microbiology at Massey University [PDF]
, 1985 Free-living amoebae (FLA) are soil organisms which have a worldwide distribution. Interest was raised when they were implicated in two fatal and several non-fatal infections in humans. This investigation involved examination of the role and/or effect of
Rogers, Lynnette Helen
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