Results 171 to 180 of about 1,615 (259)

MEN1 Deficiency Drives Lung Cancer Progression via Activation of MMP10‐Mediated Angiogenesis

Cancer Science, EarlyView.
MEN1 deficiency promotes JunD‐mediated upregulation of MMP10 expression, which cleaves pro‐HB‐EGF and activates endothelial EGFR. This triggers the PI3K/Akt and MEK/ERK signaling pathways, thereby driving angiogenesis and tumor progression. MMP10 inhibitor treatment blocks this cleavage, suppresses EGFR signaling, and thereby delays malignant ...
Chengyu Wei, Xiangyu Liu, Shimin Hu, Xiaodie Shen, Yingli Liu, Xinxin Qin, Ye Zhou, Jianqi Zheng, Bingke Tian, Jingfang Hong, Yongxia Song, Di Wang, Linlin Peng, Jinxia Ding, Fang Wang, Hui Zhang, Shihao Zhang, Huan Qiu   +17 more
wiley   +1 more source

Computational Investigation of the Potential and Limitations of Machine Learning with Neural Network Circuits Based on Synaptic Transistors. [PDF]

J Phys Chem Lett
Manzhos S, Chen QG, Lee WY, Heejoo Y, Ihara M, Chueh CC.   +5 more
europepmc   +1 more source

Graphene oxide–modified fluoridated varnish promotes mineral recovery in demineralized bovine enamel: An in vitro study

European Journal of Oral Sciences, EarlyView.
Abstract This in vitro study evaluated the efficacy of an experimental fluoridated varnish modified with graphene oxide (GO) nanoparticles in arresting initial caries lesion progression and promoting mineral recovery in demineralized bovine enamel.
Mariana Souza Rodrigues, Guilherme José Drigo, Sofia Furlanete Raymundo, Nair Cristina Brondino, Salvatore Sauro, Velo Marilia Mattar de Amoêdo Campos   +5 more
wiley   +1 more source

Building Patient Capabilities for Using Virtual Care: A Document Analysis of Patient Support Resources and Guidance. [PDF]

J Patient Exp
Walsan R, Chauhan A, Mitchell R, Adams C, Osman S, Manias E, Vandyke A, Peprah P, Newman B, Elkabbout N, Harrison R.   +10 more
europepmc   +1 more source

Does It Matter? Information Releases Before Versus After Trading Hours

European Financial Management, EarlyView.
ABSTRACT This paper shows that for firms in Pacific time zone of the United States, the effect on weekly returns from overnight returns would be 23% stronger than firms in Eastern time zone. This asymmetrical impact is documented to be associated with degrees of information transparency due to firm's different timings of information releases.
Ming‐Che Hu, Alex YiHou Huang
wiley   +1 more source

Antioxidant Activity and Potential Cholesterol Modulating Effect of Punica granatum L. Peel Hydroethanolic Extract. [PDF]

Chem Biodivers
Chaaba R, Nakbi A, Rossi I, Jrah H, Amri Z, Ferri N, Hammami S, Dall'Acqua S, Hammami M, Mehri S.   +9 more
europepmc   +1 more source

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1

The FEBS Journal, EarlyView.
Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka, Hirai Asano, Kota Toyoda, Toshiaki Nishiyori, Hidetaka Kojo, Kazuto Kiyomatsu, Katsuhisa Kurogi, Yoichi Sakakibara, Etsuko Nishimoto, Takamasa Teramoto, Yoshimitsu Kakuta   +10 more
wiley   +1 more source

Deciphering the heterogeneity and plasticity of the tumor microenvironment in liver cancer provides insights for prognosis. [PDF]

Front Pharmacol
Sun Y, Shi G, Yang J, Zhou CZ, Peng C, Luo YH, Pan Y, Wang RQ.   +7 more
europepmc   +1 more source

Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice

The FEBS Journal, EarlyView.
Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan, Caroline Uslucan, Aleyna Kizilyer, Samet Agca, Aylin Karatas, Sanaz Naghizadeh, Bahar Zehra Camurdanoglu Weber, Sukru Anil Dogan, Serkan Kir   +8 more
wiley   +1 more source

Hybrid DFT Quality Thermochemistry and Environment Effects at GGA Cost via Local Quantum Embedding. [PDF]

J Chem Theory Comput
Csóka J, Berta D, Nagy PR.
europepmc   +1 more source