Results 181 to 190 of about 33,122 (238)

Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer. [PDF]

Cell Death Dis
Luo H, Liu L, Liu X, Xie Y, Huang X, Yang M, Shao C, Li D.   +7 more
europepmc   +1 more source

TGF‐β Inhibitor Potentiates Osimertinib‐Induced Anti‐Tumor Immunity in Egfr‐Mutant Lung Cancer

Cancer Science, EarlyView.
Osimertinib enhances CD8+ T cell activity but also upregulates immunosuppressive TGF‐β in Egfr‐mutant lung tumors. This study demonstrates that TGF‐β inhibition with nintedanib or vactosertib potentiates osimertinib‐induced CD8+ T cell–mediated immunity and reduce CD206+ macrophages. These findings provide a strong rationale for novel immunotherapeutic
Tadahiro Kuribayashi, Jun Nishimura, Sachi Okawa, Masataka Taoka, Shunta Mori, Takaaki Tanaka, Tomoka Nishimura, Ayako Morita, Naofumi Hara, Kiichiro Ninomiya, Go Makimoto, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Yosuke Togashi, Yoshinobu Maeda, Katsuyuki Kiura, Kadoaki Ohashi   +17 more
wiley   +1 more source

Role of Simulated Nannochloropsis gaditana Digests in Shaping Gut Microbiota and Short-Chain Fatty Acid Levels. [PDF]

Nutrients
Paterson S, Majchrzak M, Gómez-Garre D, Ortega-Hernández A, Sánchez-González S, de la Fuente MÁ, Gómez-Cortés P, Hernández-Ledesma B.   +7 more
europepmc   +1 more source

Dentifrices for preventing erosive tooth wear: An in vitro comparative study

European Journal of Oral Sciences, EarlyView.
Abstract Erosive tooth wear is a progressive condition that compromises enamel structure and requires preventive strategies. This in vitro study aimed to compare the protective effects of fluoride‐based dentifrices containing various bioactive agents on sound enamel subjected to simulated erosive–abrasive challenges.
Juliellen Luiz da Cunha, Anderson Gomes Forte, Elizabeth Barreto Galvão de Souza, Marcel Alves Avelino de Paiva, Débora Soares Bacelar, Fábio Correia Sampaio, Andressa Feitosa Bezerra de Oliveira   +6 more
wiley   +1 more source

Ultra-broadband all-optical nonlinear activation function enabled by MoTe₂/optical waveguide integrated devices. [PDF]

Nat Commun
Chen C, Yang Z, Wang T, Wang Y, Gao K, Wu J, Wang J, Qiu J, Tan D.   +8 more
europepmc   +1 more source

Diurnal and nocturnal salivary fluoride bioavailability following brushing with high‐ or regular‐fluoride dentifrices

European Journal of Oral Sciences, EarlyView.
Abstract This study evaluated salivary fluoride (F) bioavailability during diurnal and nocturnal periods after using a high‐fluoride or regular dentifrice. Fifteen healthy adults participated in a double‐blind crossover study, brushing with either a 1450 ppm F or 5000 ppm F dentifrice.
Guereth Carvalho, Guilherme Santana, Niciane Macena, Gláuber Vale   +3 more
wiley   +1 more source

Antioxidant Activity and Potential Cholesterol Modulating Effect of Punica granatum L. Peel Hydroethanolic Extract. [PDF]

Chem Biodivers
Chaaba R, Nakbi A, Rossi I, Jrah H, Amri Z, Ferri N, Hammami S, Dall'Acqua S, Hammami M, Mehri S.   +9 more
europepmc   +1 more source

LAT1/SLC7A5‐mediated amino acid uptake is regulated by redox signals triggered by formyl‐peptide receptor 2

The FEBS Journal, EarlyView.
FPR2 activation mediates NOX‐dependent LAT1 expression and, in turn, promotes mTORC1 signaling. Upon stimulation with WKYMVm, the FPR2‐NOX2‐ROS axis upregulates LAT1 via increased c‐Myc phosphorylation and decreased miR‐126. Additionally, it promotes CD98 translocation to the plasma membrane.
Myrhiam Cassese, Chiara Brignola, Stefano Marrone, Gabriella Esposito, Rosario Ammendola, Fabio Cattaneo   +5 more
wiley   +1 more source

Analytic Gradients for Density Fitting MP2 Using Natural Auxiliary Functions. [PDF]

J Phys Chem A
Petrov K, Csóka J, Kállay M.
europepmc   +1 more source

Anemia‐associated mutations disrupt the CDIN1‐Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA‐I) disease

The FEBS Journal, EarlyView.
Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal, Tomas Brom, Ivona Nečasová, Tomáš Janovič, Pavel Veverka, Naina Verma, Lukáš Uhrík, Lenka Hernychova, Ctirad Hofr   +8 more
wiley   +1 more source