Results 21 to 30 of about 1,615 (259)
Two Competing Approaches in the Mu‘tazilite View of the Human Being: The Traditions of Abū al-Hudhayl and al-Naẓẓām [PDF]
Nazariyat: Journal for the History of Islamic Philosophy and Sciences, 2018 The aim of this article is to illustrate the two human conceptions introduced in the Basran School of Muʿtazila with their reflections on the fields like theoretical physics, epistemology, and ethics.
Yunus Cengiz
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
FEBS Open Bio, EarlyView.In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source
Nefis Nazariyesi Çerçevesinde Fahreddin er-Râzî’nin Ahlâk Düşüncesi
Cumhuriyet Üniversitesi İlahiyat Fakültesi Dergisi, 2014 Kelâm, felsefe, tefsir ve usûl-i fıkıh alanlarındaki çalışmalarıyla tanınan Eş’arî âlimi Fahreddin er-Râzî, eserlerinde genellikle akıl ve vahiy arasındaki uyum ve irtibata işaret etmektedir.
Asiye Aykıt
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Kader, 2023 The definition, nature, characteristics, and identification of the nafs are among the most fundamental problems in both metaphysics and theology. The manner in which the subject of the nafs is addressed even provides the opportunity to scrutinize the ...
Tuğba Günal
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FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
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FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
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PEMIKIRAN PARA FILOSOF MUSLIM TENTANG JIWA
An-Nida', 2014 Tulisan ini memaparkan pemikiran beberapa filosof muslim tentang jiwa. Banyak pemikiran dalam memahami keesaan Allah yang diangkat oleh berbagai aliran dalam Islam, tetapi setelah dicermati maka semuanya mengerucut pada dua kelompok saja, yaitu pemikiran
Afrizal M
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Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
Journal of Cannabis Research, 2022 Organic solvents are used for manufacturing herbal medicines and can be detected as residues of such processing in the final products. It is important for the safety of consumers to control these solvent residues.
Hendrik Jacobus Viviers +2 more
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