Results 31 to 40 of about 10,017 (288)

Two Competing Approaches in the Mu‘tazilite View of the Human Being: The Traditions of Abū al-Hudhayl and al-Naẓẓām [PDF]

Nazariyat: Journal for the History of Islamic Philosophy and Sciences, 2018
The aim of this article is to illustrate the two human conceptions introduced in the Basran School of Muʿtazila with their reflections on the fields like theoretical physics, epistemology, and ethics.
Yunus Cengiz
doaj   +1 more source

Remineralization effect of NaF, NaF with TCP, NaF with CPP‐ACP and NaF with CXP varnishes on newly erupted first permanent molars: A randomized controlled trial

International Journal of Dental Hygiene, 2023
AbstractIntroductionThe aim of this study was to evaluate the remineralization effect of NaF, NaF with TCP, NaF with CPP‐ACP and NaF with CXP varnishes on newly erupted first permanent molars using laser fluorescence (LF) method. The study was a randomized, double‐blind, controlled trial with four parallel groups.MethodsThe study was carried out in 48 ...
Merve Erkmen Almaz, Nur Burcu Ulusoy, Aylin Akbay Oba, Aysun Dokumacı   +3 more
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Kata Nafs Dalam Alquran (Kajian Analisis Semantik) [PDF]

, 2017
Penelitian ini membahas kata nafs dalam Alquran dengan menggunakan kajian Analisis Semantik. Nafs adalah istilah bahasa Arab yang dipakai dalam Alquran. Nafs merupakan bentuk jamak dari kata nufus dan anfus yang memiliki makna ruh atau jiwa.
Muzen, Nursyaidah
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Kelam’da Nefs Fenomenolojisi

Kader, 2022
Bu metin, "Kelam'da Nefs Fenomenolojisi" başlıklı doktora tezinin özetini ihtiva etmektedir.
Tuğba Günal
doaj  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Adding Tunisian grape seed extract to corn oil during heating: Impact on stability and fatty acid composition

Grasas y Aceites
A study was conducted to examine the impact of grape seed extract (GSE) on the oxidative stability of corn oil when heated. After oxidation, the peroxide (PV), p-anisidine (P-a), acidity (AV), conjugated trienes (CT), and total oxidation (TOTOX) values ...
A. Mnari Bhouri, Z. Amri, M. Dhibi, N. Koubaa, S. Hammami, M. Hammami   +5 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source