Results 41 to 50 of about 33,122 (238)

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

PENGARUH PELATIHAN TAZKIYATUN AN-NAFS IMAM AL-GHAZALI TERHADAP INTENSI AGRESI REMAJA SMA [PDF]

, 2018
Remaja merupakan individu yang memiliki intensitas untuk berperilaku agresi lebih banyak daripada anak-anak, dewasa, dan lansia. Salah satu cara yang dapat digunakan untuk mengatasi permasalahan perilaku agresi remaja adalah dengan penanganan psikologi ...
Raihanal Miski
core  

Dasatinib reverses Cancer-associated Fibroblasts (CAFs) from primary Lung Carcinomas to a Phenotype comparable to that of normal Fibroblasts [PDF]

, 2010
Cancer associated fibroblasts (CAFs) play a critical role for growth, invasion, and metastasis of cancer. Therefore, targeting CAFs with small molecule inhibitors may be an attractive anti-tumor strategy. The current study aims to identify small molecule
Silke Haubeiss, Jens O Schmid, Thomas E Mürdter, Maike Sonnenberg, Godehard Friedel, Heiko van der Kuip, Walter E Aulitzky   +6 more
core   +2 more sources

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Nefis Nazariyesi Çerçevesinde Fahreddin er-Râzî’nin Ahlâk Düşüncesi

Cumhuriyet Üniversitesi İlahiyat Fakültesi Dergisi, 2014
Kelâm, felsefe, tefsir ve usûl-i fıkıh alanlarındaki çalışmalarıyla tanınan Eş’arî âlimi Fahreddin er-Râzî, eserlerinde genellikle akıl ve vahiy arasındaki uyum ve irtibata işaret etmektedir.
Asiye Aykıt
doaj   +1 more source

An assessment of solvent residue contaminants related to cannabis-based products in the South African market

Journal of Cannabis Research, 2022
Organic solvents are used for manufacturing herbal medicines and can be detected as residues of such processing in the final products. It is important for the safety of consumers to control these solvent residues.
Hendrik Jacobus Viviers, Anél Petzer, Richard Gordon   +2 more
doaj   +1 more source

Active tectonics of Gülpınar-Tuzla area (Biga Peninsula, NW Turkey): the source of 6 February-24 March 2017 earthquake cluster

Bulletin of the Mineral Research and Exploration, 2021
The variation in the motion sense of Anatolian platelet in Aegean Sea resulted in a strike-slip tectonic regime and related neotectonic domain, the central to northern Aegean neotectonic province, which also includes both western Marmara Sea and ...
Şule Gürboğa, Ali Koçyiğit
doaj   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Gazzâlî’ye Göre Bireyin Ahlâkî Yetkinlik Kazanımında Peygamberin Rolü

Danisname Beşeri ve Sosyal Bilimler Dergisi, 2022
Bu çalışma, Gazzâlî’nin (ö. 505/1111) düşüncesinde peygamberlerin insanın ahlâkî yetkinliğini kazanmasında bir etkisinin olup olmadığını araştırmayı hedeflemektedir.
Hatice Toksöz, Ayşe Şakar
doaj   +1 more source

A comparing about purification of human soul between thought of al-kindi and zoroastrianism [PDF]

, 2018
Kindî’ye göre insan nefsinin beden ile beraber olduğu dönem içinde temizlenmesi gerekir. İnsan hayatta iken, nefis arzu gücü ve öfke gücü sayesinde ahlakî faziletlerden ayrılarak kirlenir.
Eşmeli̇, İsmet, Mutluel, Osman
core   +1 more source