Results 21 to 30 of about 116,936 (252)
Interreligiöse Aktivitäten im Ruhrgebiet
, 2012 Die religiöse Vielfalt im Ruhrgebiet ist groß, und in den letzten Jahren ist sie mehr und mehr in den Fokus von Politik und Öffentlichkeit gerückt. Die meisten Kontakte zwischen den Religionen finden aber abseits der großen Öffentlichkeit statt: in ...
Nagel, Alexander-Kenneth
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Geographies of Muslim Women: Gender, Religion and Space
Documents d'Anàlisi Geogràfica, 2006 FALAH, Ghazi-Walid; NAGEL, Caroline (eds.) (2005). Geographies of Muslim Women: Gender, Religion and Space. Nova York: The Guilford Press, 337 p.
Anna Ortiz Guitart
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Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Optimization of environmental DNA-based methods: a case study for detecting brook trout (Salvelinus fontinalis) [PDF]
PeerJThe utility of eDNA for fish species and community monitoring is well-established using targeted amplification (i.e., qPCR and ddPCR) and sequencing approaches (i.e., metabarcoding). However, the lack of optimized and standardized methods across the eDNA
Erika Myler +4 more
doaj +2 more sources
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
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, 2009 In the sixth chapter of The View from Nowhere, Thomas Nagel aims to identify a form of idealism, to isolate the argument for it and to counter this argument.
Edward, Terence Rajivan
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Análise da concepção de Nagel acerca do absurdo da vida humana
Revista TrágicaO artigo apresenta os argumentos avançados por Nagel em “The absurd” (1971) para justificar a asserção de que a vida humana é absurda ou destituída de sentido, partindo inicialmente da ideia de que o absurdo envolve sempre uma discrepância entre ...
Anamar Moncavo
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FEBS Open Bio, EarlyView.We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen +5 more
wiley +1 more source