Results 41 to 50 of about 362,006 (293)

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Hubungan Segitiga Nagel dengan Segitiga Asalnya [PDF]

, 2014
This paper discusses the relationship between the Nagel triangle and the originaltriangle. The Nagel triangle is formed by connecting the three of tangent points of theexcircle to the sides of the triangle.
Hasriati, H. (Hasriati), Natsir, M. (M), Widya, R. (Reni)   +2 more
core  

A New 3D Colon on a Chip to Decipher the Influence of Mechanical Forces on the Physiological Cellular Ecosystem

Advanced Healthcare Materials, EarlyView.
To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon‐on‐chip that integrates tunable topography, stiffness and peristalsis‐like motion within a physiologically relevant microenvironment. We showed that stretching is a dominant factor governing epithelial behavior, markedly enhancing proliferation and ...
Moencopi Bernheim‐Dennery, Lauriane Gérémie, Julie Brun, Lucas Chassatte, Giacomo Gropplero, Réda Bouras, Jieun Choo, Bertrand Cinquin, Alba Marcellan, Danijela Matic Vignjevic, Stéphanie Descroix   +10 more
wiley   +1 more source

Item-level analyses reveal genetic heterogeneity in neuroticism

Nature Communications, 2018
Neuroticism can be assessed as a composite score of individual items. Here, Nagel et al. perform genetic association studies for 12 neuroticism items and the sum-score and demonstrate genetic heterogeneity at the item-level.
Mats Nagel, Kyoko Watanabe, Sven Stringer, Danielle Posthuma, Sophie van der Sluis   +4 more
doaj   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Against Contextualism: Belief, Evidence, & the Bank Cases

Principia: An International Journal of Epistemology, 2013
Contextualism (the view that ‘knowledge’ and its variants are context-sensitive) has been supported in large part through appeal to intuitions about Keith DeRose’s Bank Cases.
Logan Paul Gage
doaj   +1 more source

White Conceptions of Racial Hierarchy: Temporary versus Permanent Preferences [PDF]

, 2006
Ideas of race, racial identity, and racial categorization, reflect the inconsistent, context-specific and fluctuating nature of racial meaning (Nagel, 1986; Forbes, 1990; Davis, 1991; Nagel, 1994; Haney-Lopez, 1995; Ignatiev, 1995; Kibria, 1996,1998 ...
Gayles, Jonathan, Tobin, Sarah
core   +1 more source

What Is It Like To Become a Bat? Heterogeneities in an Age of Extinction [PDF]

, 2018
In his celebrated 1974 essay “What Is It Like to Be a Bat?,” Thomas Nagel stages a human-bat encounter to illustrate and support his claim that “subjective experience” is irreducible to “objective fact”: because Nagel cannot experience the world as a bat
Erev, Stephanie Rhea
core   +2 more sources

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Electrochemical Modulation of Laser‐Induced Covalent Functionalization of Graphene

Advanced Science, EarlyView.
Photoelectrochemical functionalization of graphene introduces the electrochemical potential as an additional parameter for the laser‐induced covalent modification of graphene. Tuning of the potential allows for amplification or suppression of the functionalization reaction with constant laser parameters, which enables in situ Raman analysis of ...
Tamara Nagel, Linda Feuerstein, Kevin Gerein, Stefan Wolff, Janina Maultzsch, Andreas Hirsch, Inez M. Weidinger, Frank Hauke   +7 more
wiley   +1 more source