Results 31 to 40 of about 101,864 (307)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Jak to jest być nietoperzem? Refleksje przy lekturze eseju Thomasa Nagela

Zoophilologica, 2015
The article asks questions about the human cognitive abilities – how it is to be an animal of a species different from one’s own. Using as a basis the doubts of the philosopher Thomas Nagel, the author proceeds to discuss the standpoint of ethnologists ...
Dobrosława Wężowicz-Ziółkowska
doaj  

Análise da concepção de Nagel acerca do absurdo da vida humana

Revista Trágica
O artigo apresenta os argumentos avançados por Nagel em “The absurd” (1971) para justificar a asserção de que a vida humana é absurda ou destituída de sentido, partindo inicialmente da ideia de que o absurdo envolve sempre uma discrepância entre ...
Anamar Moncavo
doaj   +1 more source

Nagel, Katherina, October 23, 2010 [Interview] [PDF]

, 1920
Katherina Nagel was interviewed on Octboer 23, 2010 by Katherine Hanisko about her early life. During this time, German troops moved into her home town in Romania and evacuated them to Austria in 1944. After the Geneva Conference, her family was moved to
Nagel, Katherina
core  

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Institutioneller Wandel am Beispiel des Bologna-Prozesses [PDF]

, 2009
Politiknetzwerke sind aufgrund ihrer losen und eher informellen Struktur zu wichtigen Hoffnungsträgern innerhalb der Steuerungsforschung avanciert.
Nagel, Alexander-Kenneth
core   +2 more sources

Achteraf bekeken: Architectuur in Suriname 1951 tot 1969: Bouwwerken ontworpen door ir. P.J. Nagel (1921-1997) [PDF]

, 2005
Dit boek bestaat hoofdzakelijk uit foto’s van bouwwerken in Suriname, ontworpen door ir. Peter Jacobus Nagel in de periode 1951-1969. Ingenieur P.J. Nagel is afgestudeerd aan de Technische Hogeschool Delft.
Nagel - de Groot, M.W. (author), Nagel - de Groot, M.W.   +1 more
core  

Akteure, Beziehungen, Perspektiven [PDF]

, 2006
Die Universitäten Europas sehen sich derzeit einem nie gekannten Umbruch gegenüber. Der sogenannte "Bologna-Prozess für einen Europäischen Hochschulraum" drängt zu Vereinheitlichung und Transparenz der nationalen Hochschulsysteme.
Nagel, Alexander-Kenneth
core   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source