Results 51 to 60 of about 160,730 (303)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Natural expulsion of a sharp iron nail: Right main bronchus to the alimentary tract: A case report
Clinical Case Reports, 2021 A young girl inhaled a pointed iron nail into the right main bronchus. However, both rigid bronchoscopy and oesophagoscopy failed to locate the nail. Surprisingly, it was detected in the abdomen by C‐arm and was expelled uneventfully while defecating two
Prasanta Poudyal +4 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
, 2016 This activity proposes to balance 15 nails on the head of one nail. Nails can be balanced across the first nail if their weight is evenly distributed and if they can be stopped from slipping off.
Science Museum
core +1 more source
Travmatologiâ i Ortopediâ Rossii, 2016 The analysis of results of surgical treatment of 157 patients with proximal femur fractures was presented. In all cases the osteosynthesis using fixator PFN was performed in clinic of traumatology amd orthopedics of Moscow Municipal Hospital N 71 from ...
V. N. Borovkov +2 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Dramatic response of cutaneous, nail, and joint symptoms of psoriasis to apremilast
Clinical Dermatology Review, 2019 Apremilast has been available in India for the past 6 months as a therapy for psoriasis. A 31-year-old male patient with a diagnosis of psoriasis with oligoarthritis who was not tolerating methotrexate was treated with apremilast.
Meghana Bathina +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Dermatology Practical & Conceptual, 2020 Background: Teledermoscopy (TDS) improves diagnostic accuracy and decreases the number of unnecessary consultations. Objectives: To determine the diagnostic concordance in tertiary (dermatologist-to-experts) TDS with histopathology/follow-up–based ...
Anne Marchetti +8 more
doaj +1 more source
The Hypervascularization of the Nail Matrix and Nail Bed as a Predictor of Nail Psoriasis [PDF]
Skin Health and Disease, 2021 D. Becker-Capeller +4 more
openaire +3 more sources