Results 161 to 170 of about 56,585 (261)

Human expertise or artificial intelligence? A prospective study on nail disorder diagnosis. [PDF]

NPJ Digit Med
Brand FL, Mokhtari A, Cazzaniga S, Brand C, Franklin C, Furrer S, Grover C, Haneke E, Heidemeyer K, Iorizzo M, Junge A, Langhorst CA, Lipner SR, Naldi L, Ragonsesi TL, Rey S, Richert B, Signer B, Vogel C, Yawalkar N, Zürcher S, Obrist D, Seyed Jafari SM.   +22 more
europepmc   +1 more source

SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition

Advanced Science, EarlyView.
The SEC promotes cell identity transitions by facilitating transcription pause release at key identity‐associated genes, including Klf4 and Myc during iPSC reprogramming and Nes and Tubb3 during ESC‐to‐neuroectodermal differentiation. During early iPSC reprogramming, this function additionally involves cooperation with METTL3‐associated m6A regulation.
Zhijing Zhang, Jingyi Xu, Yonghong Wu, Yitong Qu, Xinglin Hu, Yuchen Sun, Yanshuang Wu, Zhonghua Liu, Jiaqiang Wang, Lei Lei   +9 more
wiley   +1 more source

IDEAL Phase 1 evaluation of subungual tube placement with selective nail-fold wedge resection for moderate-to-severe onychocryptosis-associated paronychia. [PDF]

Front Med (Lausanne)
Li T, Liang J, Li J, Yang F, Tian F, Xiao M, Xie C.   +6 more
europepmc   +1 more source

Targeting Nupr1‐Mediated p53 Mitochondrial Sequestration Alleviates Aortic Dissection by Restoring the Gadd45b‐Dependent Survival Program

Advanced Science, EarlyView.
This study identifies Nupr1 as a crucial stress‐responsive orchestrator driving AD. Under severe stress, Nupr1 massively accumulates within mitochondria to sequester p53, triggering apoptosis and concurrently repressing the Gadd45b‐mediated survival program.
Xi Yang, Ke‐Yuan Chen, Yue Tian, Zong‐Sheng Jiang, Jian Lei, Xing‐Hui Zhuang, Jiang‐Bin Wu, Le‐Le Tang, Hao‐Yu Li, Xiao‐Hui Chen, Yue Wang, Yu‐Mei Li, Zhi‐Huang Qiu, Zi‐Wen Cai, Liang‐Wan Chen   +14 more
wiley   +1 more source

Hybrid Osteosynthesis for Septic Humeral Shaft Nonunion in a Patient with Obesity: A Case Report. [PDF]

Cureus
Chiquini-Ramírez P, Villamues-Moreno NL, Ponce-de-Léon-Dominguez J, Moreno-Degante L, Pettet-Ruiz B, Torres-Casado E, Reyes-García HM, Garduza-Leyva N.   +7 more
europepmc   +1 more source

MPP8 Facilitates DNA DSB Repair via NHEJ to Promote Chemoresistance of TNBC Independent of Methyl‐H3K9 Binding

Advanced Science, EarlyView.
Chemoresistance is often linked to elevated DNA repair. MPP8 is found to promote breast cancer chemoresistance as a novel NHEJ accessory factor independent of its epigenetic functions. Through multiple protein interactions, MPP8 facilitates association of DNAPK and ligase complexes to promote DNA repair progression.
Rupa Kumari, Jia Fang
wiley   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

Myxoid Onychomatricoma with Unusual CD99 Expression: A Report of a Rare Case and Literature Review. [PDF]

Clin Cosmet Investig Dermatol
Zou X, Tang Z, Zhang X, Deng Y.
europepmc   +1 more source

Spatiotemporal Regulation of Hierarchical Assembly of Hydroxyapatite for Enamel Remineralization

Advanced Science, EarlyView.
Biomimetic repair exhibits unique advantages for enamel regeneration compared with conventional clinical treatments. An enzymatic mineralization system (EMS) is developed, where the resulting HAP nanorods hierarchically assemble into a highly ordered structure on the enamel surface through the spatiotemporal modulation of interfacial energies of ...
Zhenhang Tang, Zhisen Zhang, Yuanyu Zhou, Wenzhi Wu, Congrui Zhao, Chang Liu, Tong Shi, Wenjing Jin, Zhaoming Liu, Weifeng Fang, Qingyun Lin, Yi He, Zhijian Xie, Ruikang Tang, Changyu Shao, Zhuo Chen   +15 more
wiley   +1 more source

BAP1 tumor predisposition syndrome diagnosed from multiple onychopapillomas. [PDF]

JAAD Case Rep
Lin F, Saito Y, Newkirk R, Brownell I.
europepmc   +1 more source