Results 61 to 70 of about 286,980 (335)
Neurology, 2009 A 31-year-old man who had been shot with a nail gun was unresponsive at presentation, with unequal, nonreactive pupils. The frontal sinus and right frontal pole were debrided …
John Strugar, Tamara Lazic
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Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2019 The global rise in obesity has become a public health crisis. During the onset of obesity, disrupted catecholamine signals have been described to contribute to excess fat accumulation, however, the molecular and metabolic change of subcutaneous adipose ...
Shasha Zheng +15 more
doaj
Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source
Clinical Case Reports, 2020 Acquired periungual fibrokeratoma is an uncommon benign fibrous tumour occurring in the periungual area, predominantly the proximal nail fold. We describe a case of acquired periungual fibrokeratoma with an unusual presentation of mixed features ...
Kun‐Yong Sung +2 more
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Subungual Glomus Tumours: Is Magnetic Resonance Imaging or Ultrasound Necessary for Diagnosis? [PDF]
Malaysian Orthopaedic Journal, 2017 INTRODUCTION: Diagnosis of subungual glomus tumour is mostly based on detailed history and clinical examination. Recently, Magnetic Resonance Imaging (MRI) and Ultrasound have been proposed as the imaging modality to confirm the clinical diagnosis and in
Pandey CR, Singh N, Tamang B
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Dermatology Online Journal, 1985 Introductory sections on why and how to biopsy the nail unit and on the handling and processing of the specimen are followed by a presentation of normal histologic findings. These are contrasted with the abnormal changes in infections, especially fungal, of the nail unit, and in skin diseases that may affect the nail, especially psoriasis and lichen ...
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Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
The NCAR Airborne Infrared Lidar System (NAILS) [PDF]
, 1986 A planned airborne lidar system is presented which is intended to provide a remote sensing facility for a variety of applications. The eventual goal of the system development is a Doppler wind measurement capability for boundary layer dynamics and cloud ...
Lightsey, P. A., Schwiesow, R. L.
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Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source