Results 61 to 70 of about 415,928 (403)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

miR-181b functions as an oncomiR in colorectal cancer by targeting PDCD4

Protein & Cell, 2016
Programmed cell death 4 (PDCD4) is a RNA-binding protein that acts as a tumor suppressor in many cancer types, including colorectal cancer (CRC). During CRC carcinogenesis, PDCD4 protein levels remarkably decrease, but the underlying molecular mechanism ...
Yanqing Liu, Uzair-ur-Rehman, Yu Guo, Hongwei Liang, Rongjie Cheng, Fei Yang, Yeting Hong, Chihao Zhao, Minghui Liu, Mengchao Yu, Xinyan Zhou, Kai Yin, Jiangning Chen, Junfeng Zhang, Chen-Yu Zhang, Feng Zhi, Xi Chen   +16 more
doaj   +1 more source

Problematic Issues on the Organization of Selecting Person’s Biological Samples for Molecular and Genetic Examination

Bulletin of Kharkiv National University of Internal Affairs, 2021
The article is focused on the procedure of sampling as a criminal procedural action necessary for the commissioning and carrying out molecular genetic expert examination in the divisions of the Expert Service of the Ministry of Internal Affairs, namely ...
S. O. Ziubrii
doaj   +1 more source

Use of sonic tomography to detect and quantify wood decay in living trees. [PDF]

, 2016
Premise of the studyField methodology and image analysis protocols using acoustic tomography were developed and evaluated as a tool to estimate the amount of internal decay and damage of living trees, with special attention to tropical rainforest trees ...
Ballesteros, Javier O, Barrick, Pablo P, Barrios-Rodriguez, Cesar A, Bonadies, Ernesto F, Burgos, Alana C, Cedeño-Sánchez, Marjorie L, Chester, Kathleen N, Diab, Jonathan H, Faircloth, Brant C, Fossatti-Caballero, Nohely J, Fábrega, Juan Pablo, García-López, Cesar G, Gilbert, Gregory S, Glenn, Travis C, Harrower, Jennifer T, Henn, Laura AW, Hershcovich, Shiran, Holub-Young, Katharine S, Hooton, Douglas A, Hubbell, Stephen P, Johnston, Daniel C, Jordan, Fulvia A, Lumpkin, Raleigh, McWilliams, Hunter A, Pérez-Suñiga, José Moises, Renteria, Sonia A, Romo, Amanda C, Russo, Natalie, Sánchez, Juan David, Thompson, Jennifer B, Trejos-Rodríguez, Mariam M, Wong, E Beatriz   +31 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The NCAR Airborne Infrared Lidar System (NAILS) [PDF]

, 1986
A planned airborne lidar system is presented which is intended to provide a remote sensing facility for a variety of applications. The eventual goal of the system development is a Doppler wind measurement capability for boundary layer dynamics and cloud ...
Lightsey, P. A., Schwiesow, R. L.
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Emerging role of extracellular microRNAs and lncRNAs

ExRNA, 2019
The discovery of extracellular non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), has dramatically altered our understanding of the role RNA plays in organisms.
Geyu Zhou, Xi Chen
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Bjelland Vineyards Plans Grand Opening Article [PDF]

, 1970
The grand opening of Bjelland Vineyards\u27 samples and sales building is advertised, providing information about the tasting hours and the wines that will be available. The building was made from repurposed wood and square nails from a 100-year-old barn.
The News-Review
core   +1 more source