Results 71 to 80 of about 155,224 (298)
Nail changes in systemic amyloidosis
Clinical Case Reports, 2021 Nail examination must be an essential part of physical examination in our daily clinical practice, as nail changes may be the revealing sign of systemic diseases in the absence of other alarming signs.
Noureddine Litaiem +5 more
doaj +1 more source
Drug delivery into microneedle-porated nails from nanoparticle reservoirs.
Journal of Controlled Release, 2015 This study demonstrates the potential of polymeric nanoparticles as drug reservoirs for sustained topical drug delivery into microneedle-treated human nail. Laser scanning confocal microscopy was used to image the delivery of a fluorescent model compound
Wing-Sin Chiu +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Metformin induced yellow nails: a rare entity [PDF]
, 2017 This article reports an interesting and a rare case of metformin induced nail disorder in a middle aged female with type 2 diabetes. The patient had been receiving metformin one 1500mg daily from the last 6 months and noticed her finger nails gradually ...
Sharma, Tarun +2 more
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Partial removal of nail matrix in the treatment of ingrowing toe nail
Acta Orthopaedica et Traumatologica Turcica, 2020 Objectives: Ingrowing toe nail is a frequent disorder of the foot. In this study, we evaluated the results of surgical treatment of ingrowing toe nail.\r\nMethods: Sixty-two patients (31 males, 31 females; mean age 38 years; range 11 to 72 years) with ...
Nuri Aydin +2 more
doaj
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Clear Nails Plus NZ [Special Offer] Official Website Get 41% Discount
, 2020 (Special Deal) >> Click Here To Buy The Top Rated Fungal Removal Supplement at a Discounted Price Clear Nails Plus is a serious dietary enhancement that works from the back to front to calm one of toenail contagious contaminations.
Clear Nails Plus NZ
core +1 more source
Molecules, 2018 Background: The short chain fatty acid gamma-hydroxybutyric acid (GHB) is a precursor, and the metabolite of gamma-aminobutyric acid is commonly used as an illegal recreational drug of abuse.
Francesco Paolo Busardò +5 more
doaj +1 more source