Results 61 to 70 of about 255,300 (308)
miR-181b functions as an oncomiR in colorectal cancer by targeting PDCD4
Protein & Cell, 2016 Programmed cell death 4 (PDCD4) is a RNA-binding protein that acts as a tumor suppressor in many cancer types, including colorectal cancer (CRC). During CRC carcinogenesis, PDCD4 protein levels remarkably decrease, but the underlying molecular mechanism ...
Yanqing Liu +16 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Nail psoriasis: the first experience of photodynamic curcumin therapy. [PDF]
Саратовский научно-медицинский журнал, 2017 Aim: to determine the effectiveness of the photosensitizer "Curcumin" in various concentrations (0.15%, 1%, 1.5%) in combination with visible spectrum radiation in the treatment of nail psoriasis. Material and Methods.
Utz S.R. +5 more
doaj
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Emerging role of extracellular microRNAs and lncRNAs
ExRNA, 2019 The discovery of extracellular non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), has dramatically altered our understanding of the role RNA plays in organisms.
Geyu Zhou, Xi Chen
doaj +1 more source
Simple realizability of complete abstract topological graphs simplified
, 2019 An abstract topological graph (briefly an AT-graph) is a pair $A=(G,\mathcal{X})$ where $G=(V,E)$ is a graph and $\mathcal{X}\subseteq {E \choose 2}$ is a set of pairs of its edges.
Kynčl, Jan
core +1 more source
The Establishment of Child Health Cadre as Prevention for Foodborne Disease at Primary Schools [PDF]
, 2017 Personal health, including health on school-age children comes from food intake. But often, these foods can cause health problems, such as foodborne diseases.
Hargono, A. (Arief) +2 more
core +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Bed of Springs for Packaging of Microstrip Circuits in the Microwave Frequency Range [PDF]
, 2012 After the use of the bed of nails for removing cavity modes in microstrip circuit packages, we propose herein a new version of this periodic structure, based on helices (springs) instead of nails.
Kildal, Per-Simon +3 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source