Results 61 to 70 of about 102,648 (335)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

Implementasi Algoritma Naive Bayes Classifier sebagai Sistem Rekomendasi Pembimbing Skripsi [PDF]

, 2020
Dosen pembimbing memiliki peran mendampingi mahasiswa dalam proses penyusunan skripsi. Penentuan awal calon pembimbing diberbagai kampus seringkali bersifat subjektif dan kebijakan langsung oleh ketua program studi ataupun dipilih langsung oleh mahasiswa.
Asfi, Marsani, Fitrianingsih, Nopi
core   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Pendekatan Metode Ensemble Learning untuk Prakiraan Cuaca menggunakan Soft Voting Classifier

Journal of Applied Computer Science and Technology
Weather conditions are one of the crucial factors that need attention. Changes in weather conditions significantly impact various activities. Weather condition changes are determined by numerous factors, often occurring within a relatively short period ...
Steven Joses, Donata Yulvida, Siti Rochimah   +2 more
doaj   +1 more source

Machine Learning Accelerated Computational Design of Bio‐Inspired Catalysts in the Nitrogen Reduction Reaction

Advanced Materials, EarlyView.
We introduce a computational workflow that combines quantum chemical calculations and machine learning techniques to predict the catalytic performance of a wide range of catalysts in the nitrogen reduction reaction (NRR). The analysis of the trained models provides insights into the complex structure–activity relationship in experimental catalytic ...
Leonardo Di Ciano, Zihan You, Haoran Chen, Qifan Zhong, Rong‐Zhen Liao, Shaoqi Zhan   +5 more
wiley   +1 more source

Energy optimization for wireless sensor network using minimum redundancy maximum relevance feature selection and classification techniques [PDF]

PeerJ Computer Science
In wireless sensor networks (WSN), conserving energy is usually a basic issue, and several approaches are applied to optimize energy consumption. In this article, we adopt feature selection approaches by using minimum redundancy maximum relevance (MRMR ...
Muteeah Aljawarneh, Rim Hamdaoui, Ahmed Zouinkhi, Someah Alangari, Mohamed Naceur Abdelkrim   +4 more
doaj   +2 more sources

Analisis Sentimen Pindah Ibu Kota Berbasis Naive Bayes Classifier

Jurnal informatika UPGRIS, 2021
Perkembangan media sosial memudahkan pengguna dalam percepatan akses informasi di internet. Akses informasi yang awalnya sulit diperoleh begitu mudah sekarang ini.
Primandani Arsi, Bagus Adhi Kusuma, Azizan Nurhakim   +2 more
doaj   +1 more source

On Why Discretization Works for Naive-Bayes Classifiers [PDF]

, 2003
We investigate why discretization can be effective in naive-Bayes learning. We prove a theorem that identifies particular conditions under which discretization will result in naive-Bayes classifiers delivering the same probability estimates as would be obtained if the correct probability density functions were employed.
Ying Yang 0001, Geoffrey I. Webb
openaire   +1 more source