Results 31 to 40 of about 2,851 (170)

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2834-2852, August 2026.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

Hyperlipidemia Increases Nalbuphine Brain Accumulation with Multiple Dosing without Affecting Its Analgesic Response—Its Respiratory Depression Potential Should Be Investigated in Future Studies

Pharmaceuticals
Nalbuphine is associated with a significant risk of respiratory depression. Its central nervous system entry is hindered by P-glycoproteins, and lower P-glycoprotein activity is a risk factor for respiratory depression.
Marwa E. Elsherbiny, May Almukainzi, Eman Amer, Marwan Emara   +3 more
doaj   +1 more source

Analgesic effects of alpha‐2‐adrenoreceptor agonists in equine medicine: systemic, spinal, and local applications

Equine Veterinary Education, Volume 38, Issue 8, Page 442-452, August 2026.
Summary Alpha‐2‐adrenoreceptor agonists provide analgesia when used as sole agents but can also be used in combination with other drugs for their additive and potentially synergistic effects. Further, because of their effects on blood flow, alpha‐2‐adrenoreceptor agonists act to extend and perhaps intensify the effects of drugs, such as local ...
J. Brandly, J. R. Page, J. A. E. Hubbell, W. W. Muir III, K. Hopster   +4 more
wiley   +1 more source

Pain Management of Patients under General Anaesthesia Nalbuphine Alone or Nalbuphine with Ketorolac

Pakistan Armed Forces Medical Journal, 2023
Objective: To compare the efficacy of Nalbuphine alone versus Nalbuphine with Ketorolac for the management of pain in for open cholecystectomy under general anaesthesia. Study Design: Comparative prospective study.
Farrukh Shehzad, Bushra Zafar, Maqsood Ahmed, Nadia Arif, Qaseem Ahmed Raja, Nabeel Ahmed Butt   +5 more
doaj   +1 more source

Physiological mechanisms and therapeutic targets in chronic cough

Physiological Reports, Volume 14, Issue 15, August 2026.
Abstract Cough is a vital defensive reflex that safeguards the airways; however, it can become maladaptive and pathological. Chronic cough (>8 weeks in duration) affects up to 10% of the global adult population and is associated with considerable health status impairment. The understanding of cough physiology remains limited.
James C. Brown, Katherine L. Rhatigan, Oliver J. Price, Peter S. P. Cho   +3 more
wiley   +1 more source

Evaluation of the epidural analgesic effect of Nalbuphine, Lidocaine and Nalbuphine-Lidocaine combination in bucks

Beni-Suef University Journal of Basic and Applied Sciences, 2018
Nalbuphine is a lipophilic opioid which could be used subcutaneously, intramuscularly, intravenously and epidurally in human, dogs and equine but not used in bucks until yet. The aim of the existing study was to compare the analgesic effect of Nalbuphine,
G.A. Ragab, M.Z. Fathy
doaj   +1 more source

Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs [PDF]

Acta Cirúrgica Brasileira, 2014
PURPOSE: To measure the change in the minimum alveolar concentration of isoflurane (EtISO) associated with epidural nalbuphine and the postoperative analgesic requirements in dogs after ovariohysterectomy.
Fabricio de Oliveira Frazilio, Rafael DeRossi, Paulo Henrique de Affonseca Jardim, Beatriz Candolo Marques, Alessandro Rodrigues de Carvalho Martins, Larissa Correa Hermeto   +5 more
doaj   +1 more source

Preoperative Plasma and Cerebrospinal Fluid SNAP‐25 Levels Predict Delayed Neurocognitive Recovery in Elderly Patients: A Prospective Observational Study

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Preoperative SNAP‐25 levels in CSF and plasma were measured in elderly patients undergoing total knee arthroplasty, and DNR was assessed using neuropsychological tests. Lower SNAP‐25 levels predicted postoperative DNR. CSF SNAP‐25 showed better discrimination, whereas plasma SNAP‐25 demonstrated more balanced performance and greater clinical ...
Xiao‐Yu Dou, Jing‐Yu Li, Yi Qiu, Meng‐Ying Xu, Hai‐Yun Dong, Jiao Xue, Peng‐Lei Ma, Min An   +7 more
wiley   +1 more source

Characterizing treatment initiation with central nervous system–active polypharmacy among adults with dementia

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Central nervous system (CNS) –active polypharmacy, defined as concurrent use of antidepressants, antipsychotics, anti‐seizure medications, benzodiazepines, nonbenzodiazepine benzodiazepine receptor agonists, opioids, or skeletal muscle relaxants for ≥ 31 consecutive days, poses significant risks patients with dementia.
Donovan T. Maust, Rachel C. Davis, Julie Strominger, Steven C. Marcus, Hyungjin Myra Kim, Tanner Caverly, Frederic C. Blow, Lauren P. Wallner, Sarah Krein, Sarah E. Vordenberg   +9 more
wiley   +1 more source

Effects of prophylactic nalbuphine on emergence agitation and postoperative pain in pediatric patients undergoing ENT surgery with sevoflurane anesthesia

Frontiers in Pediatrics
BackgroundEmergence agitation (EA) is a common complication in the pediatric population. This study aimed to investigate the effect of the prophylactic nalbuphine on EA in pediatric patients receiving sevoflurane anesthesia.MethodsThe children undergoing
Wendong Han, Jingjie Cai, Wangping Zhang, Rong Wei, Yan Jiang   +4 more
doaj   +1 more source