Results 1 to 10 of about 1,016 (126)
Interactions Between Opioids and Dextroamphetamine on Locomotor Activity: Influence of an Opioid's Relative Efficacy at the Mu Receptor [PDF]
Frontiers in Psychiatry, 2022 Opioids and stimulants are often used in combination for both recreational and non-recreational purposes. High-efficacy mu opioid agonists generally increase the behavioral effects of stimulants, whereas opioid receptor antagonists generally attenuate ...
Mark A. Smith +16 more
doaj +2 more sources
Behavioural Effects and Naloxone Effectiveness With New Synthetic Opioids. [PDF]
Drug Alcohol RevABSTRACT Introduction The global drug market has seen an emergence of potent synthetic opioids, including benzimidazole‐derived substances known as nitazenes. These compounds have been implicated in fatal and non‐fatal overdoses. This review aims to synthesise current evidence on the pharmacological effects, potency and naloxone responsiveness of new ...
Nielsen S +8 more
europepmc +2 more sources
Advances in the Physicochemical Profiling of Opioid Compounds of Therapeutic Interest. [PDF]
ChemistryOpen, 2019 Who is in charge? In solutions, naloxone exists in four differently charged forms. Its overall lipophilicity profile indicated by the broad black line is the sum of the contributions of its four forms. Although the non‐charged form of naloxone is less lipophilic than naltrexone, its relative concentration at physiological pH is higher.
Mazák K, Noszál B, Hosztafi S.
europepmc +2 more sources
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
British Journal of Pharmacology, Volume 180, Issue S2, Page S23-S144, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander +165 more
wiley +1 more source
Drug Testing and Analysis, Volume 15, Issue 9, Page 980-986, September 2023., 2023 Hair testing provides valuable and objective information on in utero drug exposure. To obtain a complete picture of the mother's addiction behaviour and of her family background, it is advisable to collect on the day of birth or the day after birth not only hair from the mother, newborn and father but also urine from the mother and newborn. Cocaine and
Anna Bertaso +8 more
wiley +1 more source
The Oxford Catalogue of Opioids: A systematic synthesis of opioid drug names and their pharmacology
British Journal of Clinical Pharmacology, Volume 87, Issue 10, Page 3790-3812, October 2021., 2021 Aim The growing demand for analgesia, coupled with an increasing need to treat opioid dependence and overdose, has escalated the development of novel opioids. We aimed to quantify the number of opioid drugs developed and to catalogue them based on their pharmacology.
Georgia C. Richards +3 more
wiley +1 more source
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors
British Journal of Pharmacology, Volume 178, Issue S1, Page S27-S156, October 2021., 2021 The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander +154 more
wiley +1 more source
Physical Needs of Patients with Burn Injuries at Intensive Care Unit as Suggested Protocol of Nursing Care [PDF]
Helwan International Journal for Nursing Research and PracticeBackground: Patients with burn injuries have unique needs that extend outside immediate medical treatment, encompassing wound management, pain control, nutritional support, and psychological rehabilitation.
Ramadan Ramadan
doaj +1 more source
Development of natural products as drugs acting on central nervous system
Memorias do Instituto Oswaldo Cruz, 1991 We have recenty studied several natural product constituents which have effects on the CNS. (1) Tetrahydropalmatine (THP) and its analogues were isolated from Corydalis ambigua and various species of Stephania.
Xing-Zu Zhu
doaj +1 more source
Activation profiles of opioid ligands in HEK cells expressing δ opioid receptors
BMC Neuroscience, 2002 Background The aim of the present study was to characterize the activation profiles of 15 opioid ligands in transfected human embryonic kidney cells expressing only δ opioid receptors.
Clark J +3 more
doaj +1 more source