Results 11 to 20 of about 1,016 (126)
BMC Research Notes, 2012 Background Naltrexone has been proven to be an effective treatment option for the treatment of alcohol dependency. In this article we introduce a reliable and simple method developed for the simultaneous determination of naltrexone and 6-β-naltrexol in ...
Heinälä Pekka +5 more
doaj +1 more source
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors
British Journal of Pharmacology, Volume 176, Issue S1, Page S21-S141, December 2019., 2019 The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www ...
Stephen P H Alexander +138 more
wiley +1 more source
Pain Research and Management, Volume 1, Issue 2, Page 86-92, 1996., 1996 OBJECTIVE: To investigate the analgesic and nonanalgesic effects and the pharmacokinetics of an intravenous infusion of 2 mg hydromorphone over 20 mins. DESIGN: Open study. SUBJECTS: Twelve healthy volunteers. MEASUREMENTS: The analgesic effect of hydromorphone was evaluated serially using pressure pain thresholds (PPTs) measured on the third fingers ...
D Westerling +3 more
wiley +1 more source
Isolation of Nalorphine Ethereal Sulfate and Nalorphine Glucuronide from Urine of Cat and Rabbit
Experimental Biology and Medicine, 1969 SummaryIsolation of a major metabolite of nalorphine from the urine of the cat was accomplished. This metabolite was nalorphine-3-ethereal sulfate by chemical synthesis of the compound. Evidence is presented to characterize the crystalline metabolite isolated from the urine of the rabbit as nalorphine-3-glucuronide.
J M, Fujimoto +2 more
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The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
Bivalent and bitopic ligands of the opioid receptors: The prospects of a dual approach
Medicinal Research Reviews, Volume 44, Issue 6, Page 2545-2599, November 2024.Abstract Opioid receptors belonging to the class A G‐protein coupled receptors (GPCRs) are the targets of choice in the treatment of acute and chronic pain. However, their on‐target side effects such as respiratory depression, tolerance and addiction have led to the advent of the ‘opioid crisis’.
Marie Emilie Hovah, Ulrike Holzgrabe
wiley +1 more source
Effect of Nalorphine on Gastric Emptying in Man
Experimental Biology and Medicine, 1956 SummaryFive mg of nalorphine administered subcutaneously caused an average delay of over 21/2 hours in the emptying time of the stomach of 7 human subjects.
E J, VAN LIERE, D W, NORTHUP
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Chemical and Pharmaceutical Bulletin, 1970 Nalorphine-3- and -6-glucuronide were synthesized according to the method used in the synthesis of morphine glucuronides. These glucuronides were then utilized as reference standards for identification of the urinary metabolites of nalorphine in rabbits, and nalorphine-3-glucuronide was established as a major metabolite.
YOSHIMURA, HIDETOSHI +2 more
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The opioid receptor: emergence through millennia of pharmaceutical sciences. [PDF]
Front Pain Res (Lausanne), 2023 Fairbanks CA, Peterson CD.
europepmc +1 more source