Results 121 to 130 of about 2,595 (197)

Biochemical and pharmacological changes in the rat following chronic administration of morphine nalorphine and normorphine.

Journal of Pharmacology and Experimental Therapeutics, 1959
Chronic administration of morphine and morphine-nalorphine mixtures to the rat results in a profound diminution of the analgesic response to a test close of morphine (tolerance) and a profound reduction in the ability of liver enzyme preparations from ...
J. Cochin, J. Axelrod
semanticscholar   +1 more source

The effects of morphine and nalorphine-like drugs in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog.

Journal of Pharmacology and Experimental Therapeutics, 1976
A series of morphine-like and nalorphine-like drugs were studied in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog. In the nondependent dog, three profiles of activity were found which could be utilized to distinguish ...
P. Gilbert, W. Martin
semanticscholar   +1 more source

Nalorphine-induced changes in morphine self-administration in rhesus monkeys.

Journal of Pharmacology and Experimental Therapeutics, 1971
Small doses of nalorphine (30-300 µg/kg) and naloxone (3-10 µg/kg) markedly increased the rate of i.v. morphine self-administration in morphine-dependent rhesus monkeys; larger doses tended to decrease morphine self-administration.
S. Goldberg, J. Woods, C. Schuster
semanticscholar   +1 more source

Effect of morphine and nalorphine on plasma hydrocortisone levels in man.

Journal of Pharmacology and Experimental Therapeutics, 1959
The effect of therapeutic doses of morphine and nalorphine on the plasma hydrocortisone levels of normal human subjects in different test situations is reported.
R. Mcdonald, F. T. Evans, V. Weise, R. W. Patrick   +3 more
semanticscholar   +1 more source

Butorphanol, levallorphan, nalbuphine and nalorphine as antagonists in the squirrel monkey.

Journal of Pharmacology and Experimental Therapeutics, 1990
The effects of several mixed-action opioid agonist/antagonists were examined alone and in combination with the mu-opioid agonist l-methadone and the kappa-opioid agonist, trans-3,4-dichloro-N-methyl-N[2-(1-pyrrolidinyl)cyclohexyl]benzeneace tam ide (U50 ...
L. Dykstra
semanticscholar   +1 more source

Pharmacological characterization of nalorphine, a kappa 3 analgesic.

Journal of Pharmacology and Experimental Therapeutics, 1991
Nalorphine is an unusual opiate. Whereas low doses of nalorphine antagonize morphine analgesia, higher nalorphine doses are analgesic, with ED50 values (95% CL) of 13.4 (11.5, 15.8) mg/kg in the writhing and 39.5 (26.6, 60.1) mg/kg in the tail-flick ...
Dennis Paul, C. Pick, L. Tive, Gavril W. Pasternak   +3 more
semanticscholar   +1 more source

Some behavioral effects of morphine, naloxone and nalorphine in the squirrel monkey and the pigeon.

Journal of Pharmacology and Experimental Therapeutics, 1976
Morphine, naloxone and nalorphine were studied for their effects on the performance of squirrel monkeys and pigeons responding under multiple fixed-interval (FI), fixed-ratio (FR) schedules of food presentation.
S. Goldberg, W. H. Morse, D. Goldberg
semanticscholar   +1 more source

The interaction of morphine and nalorphine on respiration

Clinical Pharmacology & Therapeutics, 1968
A study was carried out in volunteers to determine the relative potency as respiratory depressants of nalorphine and morphine and their interaction when administered together. The relative potency of nalorphine when compared to morphine was found to be 0.74 (13.5 mg. nalorphine ≎ 10 mg. morphine).
J W, Bellville, G, Fleischli
openaire   +2 more sources

Aversive properties of nalorphine and naloxone in morphine-dependent rhesus monkeys.

Journal of Pharmacology and Experimental Therapeutics, 1971
Key-pressing responses of two rhesus monkeys produced i.v. injections of 0.1 mg/kg of morphine, 24 hours a day. After response rate and daily morphine intake stabilized, monkeys were continued under this schedule for one month to allow morphine ...
S. Goldberg, F. Hoffmeister, U. Schlichting, W. Wuttke   +3 more
semanticscholar   +1 more source

Demonstration of tolerance to and physical dependence of N-allylnormorphine (nalorphine).

Journal of Pharmacology and Experimental Therapeutics, 1965
Nalorphine was administered chronically to 7 subjects, using progressively increasing dose levels, to determine if tolerance and physical dependence would develop. Both physiologic and subjective responses were studied.
W. Martin, C. Gorodetzky
semanticscholar   +1 more source