Results 1 to 10 of about 59,458 (179)

Probing the Release of Bupropion and Naltrexone Hydrochloride Salts from Biopolymeric Matrices of Diverse Chemical Structures [PDF]

Polymers, 2021
In the last decades, the notion of including excipients in the formulations, as inert substances aiding production processes, has changed and they are recently viewed as multifunctional discrete entities. It is now well documented that excipients serve several roles, spreading from the stabilization and modified release, to providing biocompatible ...
Marilena Vlachou, Angeliki Siamidi, Aikaterini Dedeloudi   +2 more
exaly   +8 more sources

Effects of concurrent intravenous morphine sulfate and naltrexone hydrochloride on end-tidal carbon dioxide [PDF]

Harm Reduction Journal, 2012
Background Respiratory depression, a potentially fatal side-effect of opioid-overdose, may be reversed by timely administration of an opioid antagonist, such as naloxone or naltrexone.
Goli Veeraindar, Webster Lynn R, Lamson Michael J, Cleveland Jody M, Sommerville Kenneth W, Carter Eric   +5 more
doaj   +7 more sources

Microbiological Estimation of Nasal Spray Containing Naltrexone Hydrochloride [PDF]

Разработка и регистрация лекарственных средств, 2020
Introduction. In order to standardize the quality indicators during the expected shelf life of the developed drug naltrexone hydrochloride in the form of a nasal spray containing a high concentration of poloxamer and benzalkonium chloride as a ...
Yu. M. Domnina, V. V. Suslov, N. E. Grammatikova, S. A. Kedik   +3 more
doaj   +4 more sources

Quantitative Determination of Benzalconium Chloride in the Naltrexone Hydrochloride Nasal Spray [PDF]

Разработка и регистрация лекарственных средств, 2020
Introduction. Benzalkonium chloride is widely used as a conservation agent in medicines. For quantitative determination, the methods described in the European and American Pharmacopoeias by chromatography using columns with nitrile sorbent are often used.
Yu. M. Domnina, V. V. Suslov, S. A. Kedik, E. V. Vorfolomeeva, A. V. Meleshko   +4 more
doaj   +4 more sources

Quantitative Determination of Naltrexone Hydrochloride in a Nasal Spray by High-performance Liquid Chromatography [PDF]

Разработка и регистрация лекарственных средств, 2020
Introduction. Naltrexone, an antagonist of µ-opioid receptors, is promising for the treatment of various autoimmune and oncological diseases when used in doses of 1.5–5 mg/day. To date, there are no medications that provide such dosages of naltrexone.Aim.
Yu. M. Domnina, V. V. Suslov, S. A. Kedik, E. V. Vorfolomeeva, A. V. Meleshko   +4 more
doaj   +4 more sources

Simultaneous Transdermal Delivery of Buprenorphine Hydrochloride and Naltrexone Hydrochloride by Iontophoresis [PDF]

Molecular Pharmaceutics, 2019
The opioids buprenorphine hydrochloride (BUP) and naltrexone hydrochloride (NTX) show promise as a combination treatment for addiction, but no means of delivering the two compounds in one medicine currently exist. In this paper, we report sufficient input rates of both these drugs from one iontophoretic transdermal drug delivery system.
Maria Begoña Delgado-Charro, Stephen Husbands, Richard Guy   +2 more
exaly   +4 more sources

Microneedle-Assisted Percutaneous Delivery of Naltrexone Hydrochloride in Yucatan Minipig: In Vitro–In Vivo Correlation [PDF]

Molecular Pharmaceutics, 2013
Although microneedle-assisted transdermal drug delivery has been the subject of multiple scientific investigations, very few attempts have been made to quantitatively relate in vitro and in vivo permeation. The case of naltrexone hydrochloride is not an exception.
Nicole Brogden, Audra Stinchcomb, Priyanka Ghosh   +2 more
exaly   +5 more sources

Study of Acute Toxicity and Irritant Effect of Nasal Spray Naltrexone Hydrochloride

Разработка и регистрация лекарственных средств, 2021
Introduction. Acute toxicity of naltrexone hydrochloride nasal spray during intragastric administration to mice and local irritant effect on rabbits was studied.
Yu. M. Domnina, V. V. Suslov, S. A. Kedik, D. A. Akhmedova, A. P. Malkova   +4 more
doaj   +3 more sources

Modulators of epithelial-mesenchymal transitions in prostate cancer: potential for novel therapeutics development [PDF]

Frontiers in Pharmacology
Research in the area of hallmarks of cancer has opened the possibility of designing novel therapeutic interventions based on modulating cancer properties.
Jinxia Zheng, Ling Li, Holly Russell, Duygu Duzgun, Sebastian Oltean   +4 more
doaj   +2 more sources

Compatibility of caffeine, carvedilol, clomipramine hydrochloride, folic acid, hydrochlorothiazide, loperamide hydrochloride, methotrexate, nadolol, naltrexone hydrochloride and pentoxifylline in SyrSpend SF PH4 oral suspensions. [PDF]

Eur J Hosp Pharm, 2016
The objective of this study was to evaluate the compatibility of 10 commonly used active pharmaceutical ingredients (APIs) compounded in oral suspensions using a globally available suspending vehicle (SyrSpend SF PH4 liquid): caffeine 10.0 mg/mL, carvedilol 1.0 mg/mL, clomipramine hydrochloride 5.0 mg/mL, folic acid 1.0 mg/mL, hydrochlorothiazide 5.0 ...
Polonini HC, Silva SL, de Almeida TR, Brandão MAF, Ferreira AO.   +4 more
europepmc   +4 more sources