Results 41 to 50 of about 15,547 (188)

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

open access: yesBMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li   +9 more
wiley   +1 more source

Association between individual SNP and risk factors with nAMD and PCV risk.

open access: yes, 2015
nAMD: neovascular age-related macular degeneration; PCV: polypoidal choroidal vasculopathy; CAD: coronary artery disease. SNP: single nucleotide polymorphism.Association between individual SNP and risk factors with nAMD and PCV risk.
Lvzhen Huang (128928)   +7 more
core   +1 more source

Lower CXCR3 expression on leukocytes in patients with nAMD.

open access: yes, 2022
Median frequency (%) of leukocytes and leukocytes expressing CXCR3 in patients with neovascular AMD (nAMD), intermediate AMD (iAMD), myeloproliferative neoplasms with drusen (MPNd), and myeloproliferative neoplasms with normal retinas (MPNn) a ...
Torben Lykke Sørensen (10361516)   +4 more
core   +1 more source

Effect of High-Density Lipoprotein Metabolic Pathway Gene Variations and Risk Factors on Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in China. [PDF]

open access: yesPLoS ONE, 2015
To investigate the effect of genetic variants in the high-density lipoprotein (HDL) metabolic pathway and risk factors on neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) in China.A total of 742 Chinese ...
Qingyu Meng   +7 more
doaj   +1 more source

Visual Outcomes of Anti-VEGF Treatment on Neovascular Age-Related Macular Degeneration: A Real-World Population-Based Cohort Study

open access: yesPharmaceuticals, 2023
Neovascular age-related macular degeneration (nAMD) leads to visual impairment if not treated promptly. Intravitreal anti-VEGF drugs have revolutionized nAMD treatment in the past two decades.
Ida Korva-Gurung   +3 more
doaj   +1 more source

Effects of Biotin on a Fluorescein‐Based Photosensitizer Revealed by Multiscale Computational Modeling

open access: yesChemistry – A European Journal, EarlyView.
Biotinylation of a fluorescein‐based photosensitizer enhances its performance in PDT through a synergistic dual action. In addition to Type II singlet oxygen generation common to both dyes, the biotinylated system induces stronger membrane perturbation and higher local accumulation in lipid membranes, associated with increased water permeability and ...
Valeria Butera   +4 more
wiley   +1 more source

Confined Hot Carrier Cooling Via Excited‐State Energy Gap Engineering in Graphyne Carbon Allotropes

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
The excited‐state energy gap (EEG), regulated by the concentration of sp‐hybridized carbon, provides an effective handle for tuning electron–phonon coupling behavior. This design enables long‐lived confinement of hot carriers near the top of the EEG with controllable energy levels.
Fulong Dai   +9 more
wiley   +1 more source

Radial shape discrimination testing for new-onset neovascular age-related macular degeneration in at-risk eyes.

open access: yesPLoS ONE, 2018
We investigated the performance of the handheld radial shape discrimination (hRSD) test in detecting the development of neovascular AMD (nAMD) in a prospective, longitudinal, observational study.
Noelia Pitrelli Vazquez   +4 more
doaj   +1 more source

Artificial Intelligence in Optical Coherence Tomography‐Based Ophthalmic Imaging: From Automated Diagnosis to Personalized Disease Monitoring

open access: yesEye &ENT Research, EarlyView.
ABSTRACT Artificial intelligence (AI) is increasingly applied to optical coherence tomography (OCT) in ophthalmology, but evidence for automated diagnosis is stronger than evidence for longitudinal monitoring. This narrative review evaluates OCT‐based AI with emphasis on disease monitoring and progression, particularly in retinal disease and glaucoma ...
Stjepan Škudar
wiley   +1 more source

Simultaneous development of full-thickness macular hole and neovascular age-related macular degeneration

open access: yesAmerican Journal of Ophthalmology Case Reports, 2022
Purpose: To present a case of full-thickness macular hole (MH) with treatment-naïve neovascular age-related macular degeneration (nAMD). Observations: A 74-year-old woman presented with sudden visual impairment and floaters in her left eye.
Shuichiro Aoki, Hiroko Imaizumi
doaj   +1 more source

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