Results 51 to 60 of about 22,786 (211)

Plasma level of lipocalin 2 is increased in neovascular age-related macular degeneration patients, particularly those with macular fibrosis

Immunity & Ageing, 2020
Background Previously, we and others have reported higher populations of circulating neutrophils in patients with neovascular age-related macular degeneration (nAMD).
Mei Chen, Nan Yang, Judith Lechner, Levente Toth, Ruth Hogg, Giuliana Silvestri, Usha Chakravarthy, Heping Xu   +7 more
doaj   +1 more source

Implicit Ligand Theory: Rigorous Binding Free Energies and Thermodynamic Expectations from Molecular Docking

, 2012
A rigorous formalism for estimating noncovalent binding free energies and thermodynamic expectations from calculations in which receptor configurations are sampled independently from the ligand is derived.
Minh, David D. L.
core   +1 more source

Substrate-Specific Inhibition Constants for Phospholipase A2 Acting on Unique Phospholipid Substrates in Mixed Micelles and Membranes Using Lipidomics. [PDF]

, 2019
Assaying lipolytic enzymes is extremely challenging because they act on water-insoluble lipid substrates, which are normally components of micelles, vesicles, and cellular membranes.
Armando, Aaron, Dennis, Edward A, Mouchlis, Varnavas D   +2 more
core   +6 more sources

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

Confined Hot Carrier Cooling Via Excited‐State Energy Gap Engineering in Graphyne Carbon Allotropes

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
The excited‐state energy gap (EEG), regulated by the concentration of sp‐hybridized carbon, provides an effective handle for tuning electron–phonon coupling behavior. This design enables long‐lived confinement of hot carriers near the top of the EEG with controllable energy levels.
Fulong Dai, Zhaozhao Xiong, Yingcong Liu, Feiyu Cheng, Haochun Sun, Zhenfa Zheng, Jin Zhao, Zhuojian Liang, Zhuo Kang, Yue Zhang   +9 more
wiley   +1 more source

Effect of High-Density Lipoprotein Metabolic Pathway Gene Variations and Risk Factors on Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in China. [PDF]

PLoS ONE, 2015
To investigate the effect of genetic variants in the high-density lipoprotein (HDL) metabolic pathway and risk factors on neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) in China.A total of 742 Chinese ...
Qingyu Meng, Lvzhen Huang, Yaoyao Sun, Yujing Bai, Bin Wang, Wenzhen Yu, Mingwei Zhao, Xiaoxin Li   +7 more
doaj   +1 more source

Achieving Multiswitchable Phases to Govern Enhanced Photocatalysis in Staggered In2Se3/SnSe Heterostructure

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Multiswitching between type‐II and Z‐scheme phases within a pristine In2Se3/SnSe heterostructure enable controllable carrier dynamics and enhanced photocatalytic performance. Two‐dimensional staggered heterostructures, featuring by the intrinsically facilitate charge separation, provide promising platforms for efficient photocatalytic water splitting ...
Keying Han, Yitong Liang, Nana Hu, Defeng Guo, Thomas Frauenheim, Yingchun Cheng, Xingshuai Lv, Qiang Wang   +7 more
wiley   +1 more source

Providing a Safe and Effective Intravitreal Treatment Service: Strategies for Service Delivery

Clinical Ophthalmology, 2020
Winfried Amoaku,1 Clare Bailey,2 Louise Downey,3 Richard P Gale,4 Faruque Ghanchi,5 Robin Hamilton,6 Sajjad Mahmood,7 Geeta Menon,8 Jenny Nosek,9 Ian Pearce,10 Yit Yang11 1Academic Ophthalmology, Division of Clinical Neuroscience, University of ...
Amoaku W, Bailey C, Downey L, Gale RP, Ghanchi F, Hamilton R, Mahmood S, Menon G, Nosek J, Pearce I, Yang Y   +10 more
doaj  

Prevention Surpasses Treatment: 5-year Follow-Up, Cost-Utility, and Cost–Benefit of Zeaxanthin Therapy for Neovascular Age-Related Macular Degeneration

Ophthalmology and Therapy, 2023
Introduction Oral administration of zeaxanthin (Zx) 20 mg daily in patients with unilateral neovascular age-related macular degeneration (nAMD) treated with triple therapy (photodynamic therapy/intravitreal bevacizumab/intravitreal dexamethasone) reduced
Gary C. Brown, Melissa M. Brown, Dennis Gierhart, R. Joseph Olk   +3 more
doaj   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source