Results 51 to 60 of about 15,547 (188)

Stoichiometric Binding of Cyclophilin‐A to The HIV‐1 Capsid Modulates Its Mechanoelastic Properties

Small, EarlyView.
The HIV‐1 capsid is a protein nanocapsule that must balance rigidity and flexibility to enter the cell nucleus. Atomic force microscopy simulations reveal that binding of the host protein Cyclophilin A tunes this mechanical response: partial coverage preserves deformability, while excessive binding induces brittleness and failure.
Juan S. Rey, Alexander J. Bryer, Juan R. Perilla   +2 more
wiley   +1 more source

NAMD: A Portable and Highly Scalable Program for Biomolecular Simulations [PDF]

, 2009
NAMD is a portable parallel application for biomolecular simulations. NAMD pioneered the use of hybrid spatial and force decomposition, a technique used by most scalable programs for biomolecular simulations, including Blue Matter and Desmond which were ...
Phillips, James C., Kumar, Sameer, Kale, Laxmikant V., Mei, Chao, Zheng, Gengbin, Bhatele, Abhinav   +5 more
core  

Моделирование ИК-спектров массива углеродных нанотрубок в пакете NAMD [PDF]

, 2012
Рассмотрена возможность спектрального контроля геометрических параметров массивов углеродных нанотрубок. На основе молекулярно-динамического моделирования в пакете NAMD получены спектры поглощения электромагнитных волн в диапазоне частот О - 500 см-1 в ...
Баркалин, В. В., Плетежов, А. А.   +1 more
core   +1 more source

Safety and effectiveness of brolucizumab in patients with neovascular age-related macular degeneration: A phase IV study from India

Indian Journal of Ophthalmology
Purpose: The purpose of this study is to evaluate the safety and effectiveness of brolucizumab intravitreal injections (IVI) in Indian patients with neovascular age-related macular degeneration (nAMD).
Asim K Ghosh, Debdulal Chakraborty, Aditya Sudhalkar, Rohan Chawla, Simar R Singh, Atul K Sahu, Ramesh Venkatesh, Vishal Raval, Sonali Shah, Padma Preetha, Maulik Bhavsar, Sandip Patil, Isha Khadke, Anup Thorat   +13 more
doaj   +1 more source

Prevention Surpasses Treatment: 5-year Follow-Up, Cost-Utility, and Cost–Benefit of Zeaxanthin Therapy for Neovascular Age-Related Macular Degeneration

Ophthalmology and Therapy, 2023
Introduction Oral administration of zeaxanthin (Zx) 20 mg daily in patients with unilateral neovascular age-related macular degeneration (nAMD) treated with triple therapy (photodynamic therapy/intravitreal bevacizumab/intravitreal dexamethasone) reduced
Gary C. Brown, Melissa M. Brown, Dennis Gierhart, R. Joseph Olk   +3 more
doaj   +1 more source

How We Simulate Nanopores

Small Methods, EarlyView.
Nanopore technology has revolutionized single‐molecule sensing, yet it suffers from an inherent interpretive challenge. Molecular dynamics has emerged as a go‐to method for determining the relationship between the structure of translocating molecules and the nanopore current signals.
Behzad Mehrafrooz, Xavier Mleziva, Meng Xu, Melika Shekari, Christopher Maffeo, Aleksei Aksimentiev   +5 more
wiley   +1 more source

Association between the cumulative effects of the SNPs and nAMD and PCV risk.

, 2015
ORa, odds ratio of PCV to controlORb, odds ratio of AMD to controlnAMD: neovascular age-related macular degeneration; PCV: polypoidal choroidal vasculopathy.Association between the cumulative effects of the SNPs and nAMD and PCV risk.
Lvzhen Huang (128928), Qingyu Meng (832290), Yujing Bai (170144), Wenzhen Yu (128933), Xiaoxin Li (128947), Bin Wang (30851), Mingwei Zhao (167087), Yaoyao Sun (167078)   +7 more
core   +1 more source

The optical coherence tomography and microperimetry biomarker evaluation in patients with geographic atrophy (OMEGA) study: Geographic atrophy progression in fundus autofluorescence ‐ OMEGA report 3

Acta Ophthalmologica, EarlyView.
Abstract Purpose To measure the progression of geographic atrophy (GA) in subjects with age‐related macular degeneration (AMD) in a natural history study. Methods We analysed fundus autofluorescence (FAF) images using a semiautomatic method (RegionFinder) to quantify the GA area in a monocentric study.
Philippe Valmaggia, Georg Ansari, Nadja Inglin, Nils Schärer, Hanna Zuche, Chrysoula Gabrani, Faady Yahya, Marco Cattaneo, Kristina Pfau, Andrea Giani, Marieh Esmaeelpour, Taffeta Chingning Yamaguchi, Christian Prünte, Hendrik P. N. Scholl, Nicolas Feltgen, Leopold Schmetterer, Maximilian Pfau, Peter M. Maloca   +17 more
wiley   +1 more source

Summary of Multifactor Dimensionality Reduction (MDR) results for interactions analysis on nAMD and PCV risk.

, 2015
CVC—Cross-validation consistencyP-value based on 10 000 permutationsBest model with highest CVC and accuracy in bold.nAMD: neovascular age-related macular degeneration; PCV: polypoidal choroidal vasculopathy.Summary of Multifactor Dimensionality ...
Lvzhen Huang (128928), Qingyu Meng (832290), Yujing Bai (170144), Wenzhen Yu (128933), Xiaoxin Li (128947), Bin Wang (30851), Mingwei Zhao (167087), Yaoyao Sun (167078)   +7 more
core   +1 more source

Impact of neovascular age-related macular degeneration: burden of patients receiving therapies in Japan

Scientific Reports, 2021
The chronic eye disorder, neovascular age-related macular degeneration (nAMD), is a common cause of permanent vision impairment and blindness among the elderly in developed countries, including Japan. This study aimed to investigate the disease burden of
Shigeru Honda, Yasuo Yanagi, Hideki Koizumi, Yirong Chen, Satoru Tanaka, Manami Arimoto, Kota Imai   +6 more
doaj   +1 more source