Results 71 to 80 of about 15,547 (188)
Medicinal Research Reviews, Volume 46, Issue 6, Page 1939-1957, November 2026.ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay +3 more
wiley +1 more source
Risk of Parkinson’s disease in patients with neovascular age-related macular degeneration
Journal of Current Ophthalmology, 2018 Purpose: To examine the risk of developing Parkinson's Disease (PD) in patients who are newly diagnosed with neovascular age-related macular degeneration (nAMD).
Mahyar Etminan, Ali Samii, Bonnie He
doaj +1 more source
Capturing Hu Antigen R Domain Closure Through Supervised Molecular Dynamics Simulations
ChemMedChem, Volume 21, Issue 19, 14 October 2026.HuR is a therapeutically relevant RNA‐binding protein that switches from an open apo form to a closed RNA‐bound one. Its atomistic detail is unknown. Here, Supervised Molecular Dynamics is applied for the first time to an intramolecular event: a multistep supervision of interdomain distances reproduces a plausible closure pathway and reveals transient ...
Chiara Cavastracci Strascia +6 more
wiley +1 more source
Photodiagnosis and Photodynamic TherapyPurpose: To evaluate wide-field choroidal alterations in intermediate AMD (iAMD) and neovascular AMD (nAMD) using ultra-widefield swept-source optical coherence tomography angiography (UWF SS-OCTA).
Xianggui Zhang +5 more
doaj +1 more source
FEBS Open Bio, Volume 16, Issue 10, Page 1870-1883, October 2026.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
ANALISIS KINERJA SISTEM CLUSTER TERHADAP APLIKASI SIMULASI DINAMIKA MOLEKULAR NAMD MEMANFAATKAN PUSTAKA CHARM++ [PDF]
, 2004 PROGRAM namd mampu untuk memenuhi semua kriteria yang ...
Yulianto , Chandra +2 more
core
From Molecular Targets to Advanced Delivery Systems: Aptamers for Precision Ocular Therapeutics
Advanced Therapeutics, Volume 9, Issue 10, October 2026.Aptamer‐based strategies are revolutionizing ocular disease management through highly specific molecular recognition of disease specific molecular targets. This review systematically integrates therapeutic aptamer sequences, diagnostic aptasensor platforms, and targeted delivery strategies, highlighting design principles, ocular bioavailability ...
Minal Thacker +4 more
wiley +1 more source
ObjectiveNeovascular age-related macular degeneration (nAMD) is characterized by pathological neovascularization in the macula, leading to irreversible central vision loss.
Xiao Ke +17 more
core +1 more source
JFO Open OphthalmologyPurpose: To compare the demographics, clinical presentation, and outcomes of intravitreal (IV) anti-VEGF monotherapy in the management of treatment-naïve polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD) in ...
Ogugua Ndubuisi Okonkwo +4 more
doaj +1 more source
Scientific Reports, 2018 This study investigated the pathophysiological features of pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) by analysing and comparing cytokine profiles in aqueous humour (AH) collected from 18 PNV, 18 nAMD and ...
Nobuhiro Terao +11 more
doaj +1 more source