Results 51 to 60 of about 773,104 (270)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Neural overlap of L1 and L2 semantic representations across visual and auditory modalities : a decoding approach/ [PDF]

open access: yes, 2018
This study investigated whether brain activity in Dutch-French bilinguals during semantic access to concepts from one language could be used to predict neural activation during access to the same concepts from another language, in different language ...
De Baene, Wouter   +3 more
core   +4 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

A prognostic signature for hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer

open access: yesScientific Reports
Hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) is the most common molecular subtype in breast cancer (BC), but drug resistance remains an unsolved problem, particularly in metastatic ones.
Yincheng Liu   +12 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Naming, Order and Power: She Unnames Them All of Ursula & Lord of the Rings of Tolkien

open access: yesİstanbul Hukuk Mecmuası
One of the two points that establishes a relationship between law and literature is the legal themes in literary works, and the other is the literary character of law itself.
O. Vahdet İşsevenler
doaj   +1 more source

Phonographic neighbors, not orthographic neighbors, determine word naming latencies [PDF]

open access: yes, 2007
The orthographic neighborhood size (N) of a word—the number of words that can be formed from that word by replacing one letter with another in its place—has been found to have facilitatory effects in word naming.
Adelman, James S.   +1 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

"Meninos" e "Professoras"? Pragmática social numa instituição de cuidado de deficientes

open access: yesDELTA: Documentação de Estudos em Lingüística Teórica e Aplicada
RESUMO Apoiado em teses de Kanavillil Rajagopalan, para quem toda representação é política, pois é uma escolha dentre representações possíveis, e de Howard Becker, para quem toda representação é adequada a determinadas condições sociais de fazer e uso ...
Ubiratan Garcia VIEIRA
doaj   +1 more source

Mycobacterium tuberculosis lineage: a naming of the parts [PDF]

open access: yes, 2005
There have been many reports of groups of related Mycobacterium tuberculosis strains described variously as lineages, families or clades. There is no objective definition of these groupings making it impossible to define relationships between those ...
Bellamy   +25 more
core   +1 more source

Home - About - Disclaimer - Privacy