Results 51 to 60 of about 208,959 (312)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Brain Areas Critical for Picture Naming: A Systematic Review and Meta-Analysis of Lesion-Symptom Mapping Studies [PDF]

, 2023
Lesion-symptom mapping (LSM) studies have revealed brain areas critical for naming, typically finding significant associations between damage to left temporal, inferior parietal, and inferior fontal regions and impoverished naming performance.
Vitória Piai, Dilys Eikelboom, Piai, V., Eikelboom, D.   +3 more
core   +1 more source

A prognostic signature for hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer

Scientific Reports
Hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) is the most common molecular subtype in breast cancer (BC), but drug resistance remains an unsolved problem, particularly in metastatic ones.
Yincheng Liu, Ningyi Xue, Feidie Duan, Kunli Zhao, Yan Liang, Jing Zhao, Lei Zhang, Yu Xu, Yuzi Zhang, Guoqiang Wang, Shangli Cai, Tianyu Zeng, Shui Wang   +12 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Early Activity in Broca's Area During Reading Reflects Fast Access to Articulatory Codes From Print

, 2014
Prior evidence for early activity in Broca's area during reading may reflect fast access to articulatory codes in left inferior frontal gyrus pars opercularis (LIFGpo).
Simpson, Michael I G, Cornelissen, Piers, Simpson, Michael I. G., Katherine L. Wheat, Piers L. Cornelissen, Hansen, P.C., Wheat, Katherine, Wheat, K.L., Simpson, Michael IG, Michael I. G. Simpson, Wheat, Katherine L, Peter C. Hansen, Simpson, Michael, Jonathan Grainger, Millman, Rebecca E, Rebecca E. Millman, Wheat, Katherine L., Hansen, Peter C, Hansen, Peter, Cornelissen, Piers L, Klein, Michael, Grainger, J., Millman, R.E., Grainger, Jonathan, Klein, M., Simpson, M.I., Michael Klein, Hansen, Peter C; id_orcid, Cornelissen, P.L., Millman, Rebecca E., Hansen, Peter C., Cornelissen, Piers L., Millman, Rebecca, Millman, Rebecca E; id_orcid   +33 more
core   +1 more source

Naming, Order and Power: She Unnames Them All of Ursula & Lord of the Rings of Tolkien

İstanbul Hukuk Mecmuası
One of the two points that establishes a relationship between law and literature is the legal themes in literary works, and the other is the literary character of law itself.
O. Vahdet İşsevenler
doaj   +1 more source

Noms, étiquette(s) et identités dans Persuasion, de Jane Austen

Cahiers Victoriens et Edouardiens, 2014
Jane Austen’s last novel, Persuasion, dramatises the tensions inherent in the decline of the ancient landed order and of its traditional sources of authority, as the emergence of a new social hierarchy, in the wake of the Napoleonic wars, was leading to ...
Marie-Laure Massei
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Left posterior BA37 is involved in object recognition: a TMS study

, 2000
Functional imaging studies have proposed a role for left BA37 in phonological retrieval, semantic processing, face processing and object recognition. The present study targeted the posterior aspect of BA37 to see whether a deficit, specific to one of the
Stewart, Lauren, Meyer, Bernd-Ulrich, Bernd-Ulrich Meyer, Rothwell, J., Lauren Stewart, Meyer, B.-U., Frith, U., John Rothwell, Stewart, L.; id_orcid, Uta Frith, Frith, Uta, Rothwell, John   +11 more
core   +1 more source