Results 191 to 200 of about 15,085 (211)

Spatially resolved endothelial signaling via nampt-itga5 drives immune evasion in stem-like gastric cancer. [PDF]

Cancer Immunol Immunother
Sung JY, Cheong JH, Kim ET.
europepmc   +1 more source

Enhanced tumor suppression in patient-derived temozolomide-resistant glioblastoma cells using a combination treatment of Olaparib and FK866. [PDF]

BMC Cancer
Sha X, Li J, Fang Y, Feng J, Feng Y, Wang J, Si Y, Li F, Cheng S, Ding W.   +9 more
europepmc   +1 more source

Jianpi-Huogu Prescription Repairs Nontraumatic Osteonecrosis of the Femoral Head by Inhibiting NAMPT/STK11/HMGCR/ACAT1 Axis-Mediated Lipid Production. [PDF]

J Cell Mol Med
Li T, Ma Z, Gao S, Zhang C, Jia Y, Feng H, Lin N, Chen W, Zhang Y.   +8 more
europepmc   +1 more source

Intermedin Inhibits DNA Damage-Promoted Senescent Phenotype Transition of Vascular Smooth Muscle Cells in Aorta by Activating NAMPT/PARP1 in Mice. [PDF]

Pharmaceuticals (Basel)
Ji DR, Chen Y, Zhu HX, Liu SM, Wu N, Zhang YR, Zhao J, Yu YR, Jia MZ, Han L, Tang CS, Chen LL, Zhou YB, Qi YF.   +13 more
europepmc   +1 more source

Adipocytes Promote Cisplatin Resistance through Secreting A1BG and Regulating NAMPT/PARP1 Axis-Mediated DNA Repair in Osteosarcoma. [PDF]

Adv Sci (Weinh)
Liang Y, Li Z, Tang L, Pan Z, Fei X, Tan C, He A, Yang Q, Cheng D.   +8 more
europepmc   +1 more source

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NAMPT and NAMPT-controlled NAD Metabolism in Vascular Repair

Journal of Cardiovascular Pharmacology, 2016
Vascular repair plays important roles in postischemic remodeling and rehabilitation in cardiovascular and cerebrovascular disease, such as stroke and myocardial infarction. Nicotinamide adenine dinucleotide (NAD), a well-known coenzyme involved in electron transport chain for generation of adenosine triphosphate, has emerged as an important controller ...
Pei, Wang, Wen-Lin, Li, Jian-Min, Liu, Chao-Yu, Miao   +3 more
openaire   +2 more sources

Nampt Potentiates Antioxidant Defense in Diabetic Cardiomyopathy

Circulation Research, 2021
Rationale: Diabetic cardiomyopathy is accompanied by increased production of NADH, predominantly through oxidation of fatty acids and consequent increases in oxidative stress. The role of Nampt (nicotinamide phosphoribosyltransferase), the rate-limiting enzyme of the salvage pathway of nicotinamide adenine dinucleotide ...
Shin-ichi Oka, Jaemin Byun, Chun-yang Huang, Nobushige Imai, Guersom Ralda, Peiyong Zhai, Xiaoyong Xu, Sanchita Kashyap, Junco S. Warren, John Alan Maschek, Trevor S. Tippetts, Mingming Tong, Sundararajan Venkatesh, Yoshiyuki Ikeda, Wataru Mizushima, Toshihide Kashihara, Junichi Sadoshima   +16 more
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Medicinal Chemistry of Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors

Journal of Medicinal Chemistry, 2013
Nicotinamide phoshophoribosyltransferase (NAMPT) plays a key role in the replenishment of the NAD pool in cells. This in turn makes this enzyme an important player in bioenergetics and in the regulation of NAD-using enzymes, such as PARPs and sirtuins. Furthermore, there is now ample evidence that NAMPT is secreted and has a role as a cytokine.
GALLI, Ubaldina, TRAVELLI, Cristina, MASSAROTTI, Alberto, Fakhfouri, G, Rahimian, R, TRON, Gian Cesare, GENAZZANI, Armando   +6 more
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NAMPT as a Therapeutic Target against Stroke

Trends in Pharmacological Sciences, 2015
Nicotinamide phosphoribosyltransferase (NAMPT), also an adipokine known as visfatin, acts via enzymatic activity to synthesize nicotinamide mononucleotide (NMN) and then to maintain homeostasis of nicotinamide adenine dinucleotide (NAD), which plays a dual role in energy metabolism and biological signaling. Of note, the NAMPT metabolic pathway connects
Pei, Wang, Chao-Yu, Miao
openaire   +2 more sources