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Frontiers in Toxicology, 2022 New Approach Methodologies (NAMs) are any non-animal-based approaches that can provide information in the context of chemical hazard and safety assessment. The goal is to develop information with equivalent or better scientific quality and relevance than
Izabel Vianna Villela +1 more
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New approach methodologies in human regulatory toxicology – Not if, but how and when!
Environment International, 2023 The predominantly animal-centric approach of chemical safety assessment has increasingly come under pressure. Society is questioning overall performance, sustainability, continued relevance for human health risk assessment and ethics of this system ...
Sebastian Schmeisser +28 more
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Thoracic Research and PracticeEnvironmental exposures experienced throughout life, collectively referred to as the exposome, play a fundamental role in shaping epithelial barrier integrity, repair capacity, and vulnerability to disease.
Pelin Saglam-Metiner +15 more
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A NAMs-Based Microphysiological System for Metastasis and Mechanobiology Studies
Thoracic Research and PracticeINTRODUCTION: Lung and breast cancers are among the most common types of cancer worldwide, with approximately 2.5 million new cases occurring each year.1 Lung cancer often remains asymptomatic until advanced stages, leading to delayed diagnosis and high ...
Basar Dogan +3 more
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A method to predict overall food preferences.
PLoS ONE, 2022 Most natural ecosystems contain animals feeding on many different types of food, but it is difficult to predict what will be eaten when food availabilities change. We present a method that estimates food preference over many study sites, even when number
Vilis O Nams, Matt W Hayward
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环境与职业医学BackgroundNitrosamines (NAms), emerging as disinfection by-products in drinking water, are highly carcinogenic. Given the significant NAms contamination reported in various regions of China, evaluating the contamination levels and health risks of NAms in
Ting WANG +4 more
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Modernizing Medical Research to Benefit People and Animals
Animals, 2022 In the context of widespread public and political concern around the use of animals in research, we sought to examine the scientific, ethical and economic arguments around the replacement of animals with New Approach Methodologies (NAMs) and to situate ...
Isobel Hutchinson +2 more
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BMEMat, EarlyView.This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu +9 more
wiley +1 more source
Business Strategy and the Environment, EarlyView.ABSTRACT The rapid proliferation of chemicals and nanomaterials (CNMs) has resulted in significant cross‐sector innovation, delivering product enhancements such as improved UV protection and waterproof textiles. However, these advances present urgent challenges regarding human safety, environmental hazards, and regulatory compliance. Despite the recent
Alessandra Fiorucci +4 more
wiley +1 more source
Carbon Energy, EarlyView.Replacing the oxygen evolution reaction with the electro‐oxidation of pollutants and waste streams offers an energy‐efficient route for simultaneous hydrogen production and pollutant remediation. This review summarizes the reaction mechanisms, catalyst design principles, and emerging paired‐electrolysis strategies that govern activity, selectivity ...
Safa Al‐Yahyaey +4 more
wiley +1 more source