Results 31 to 40 of about 7,734 (200)

Partial mGlu5 Negative Allosteric Modulator M-5MPEP Demonstrates Antidepressant-Like Effects on Sleep Without Affecting Cognition or Quantitative EEG

Frontiers in Neuroscience, 2021
Selective negative allosteric modulators (NAMs) targeting the metabotropic glutamate receptor subtype 5 (mGlu5) demonstrate anxiolytic-like and antidepressant-like effects yet concern regarding adverse effect liability remains.
Kimberly M. Holter, Alex D. Lekander, Christina M. LaValley, Elizabeth G. Bedingham, Bethany E. Pierce, L. Paul Sands, Craig W. Lindsley, Craig W. Lindsley, Craig W. Lindsley, Carrie K. Jones, Carrie K. Jones, Robert W. Gould   +11 more
doaj   +1 more source

The Impact of Glycation on Protein Digestibility

ChemFoodChem, EarlyView.
Schematic overview of how protein glycation affects digestibility and downstream nutritional consequences. Glycation‐derived structural modifications reduce protease accessibility, leading to limited hydrolysis and altered peptide generation. These changes decrease amino acid bioavailability and may subsequently contribute to microbiome alterations ...
Lea Hönemann, Simone Lipinski, Jana Raupbach   +2 more
wiley   +1 more source

Hippocampal α5-GABAA Receptors Modulate Dopamine Neuron Activity in the Rat Ventral Tegmental Area

Biological Psychiatry Global Open Science, 2023
Background: Aberrant dopamine neuron activity is attributable to hyperactivity in hippocampal subfields driving a pathological increase in dopamine neuron activity, which is positively correlated with psychosis in humans.
Stephanie M. Perez, Alexandra M. McCoy, Thomas D. Prevot, Md Yeunus Mian, Flavia R. Carreno, Alan Frazer, James M. Cook, Etienne Sibille, Daniel J. Lodge   +8 more
doaj   +1 more source

Nichtlineare Staubungsneigung binärer Schüttgutmischungen: Herausforderungen bei der Prognose Non‐linear dusting tendency of binary bulk material mixtures: Challenges in prognosis

Chemie Ingenieur Technik, EarlyView.
Aufgrund überlagerter oder konkurrierender Mechanismen sind relevante Wechselwirkungen bei der Staubung von Schüttgutmischungen komplex und nur unzureichend verstanden. Selbst für Mischungen aus umfassend charakterisierten Einzelkomponenten existieren keine belastbaren Modelle. In dieser Arbeit werden die Hürden bei der Prognose thematisiert.
David Horst, Anke Helfer, Eberhard Schmidt   +2 more
wiley   +1 more source

An analysis of trends in the use of animal and non-animal methods in biomedical research and toxicology publications

Frontiers in Lab on a Chip Technologies
IntroductionThere have been relatively few attempts to quantitatively assess if, and in which areas, the use of non-animal methods (NAMs) is increasing in biomedical research and importantly, how this compares to the use of live animals.MethodsWe ...
Katy Taylor, Stephanie Modi, Jarrod Bailey   +2 more
doaj   +1 more source

Homophily‐adjusted social influence estimation

Canadian Journal of Statistics, EarlyView.
Abstract Homophily and social influence are two key concepts of social network analysis. Distinguishing between these phenomena is difficult, and approaches to disambiguate the two have been primarily limited to longitudinal data analyses. In this study, we provide sufficient conditions for valid estimation of social influence through cross‐sectional ...
Hanh T.D. Pham, Daniel K. Sewell
wiley   +1 more source

A Comparative Study of DC Beads, Callispheres and Multimodal Imaging Nano-Assembled Microspheres Loaded with Irinotecan in Vitro

Technology in Cancer Research & Treatment
Introduction: In recent years, the development of drug-eluting embolization beads that can be imaged has become a hot research topic in regard to meeting clinical needs.
Jieyu Wang MD, Shaoya Zhang MD, Yiwei He MD, Wan Sun MD, Xiaoyang Zhu MD, Zihan Xi MD, Qian Ma MD, Yuanxin Ye MD, Ziyang Song MD, Yuqing Zhang PhD, Guoliang Shao PhD   +10 more
doaj   +1 more source

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source

Advancing Pregnancy and Pediatric Science through the NIH Transporter Elucidation Network

Clinical Pharmacology &Therapeutics, EarlyView.
Human gestation is characterized by dynamic changes in maternal physiology and maturation of tissue functions before and after birth. The fetus and neonate are highly dependent upon transfer of maternal nutrients via the placenta and lactating mammary gland, which frequently involve selective membrane transporter proteins.
Joanne Wang, Jashvant D Unadkat, Samuel LM Arnold, John K Fallon, Pouria Fattahi, Dan Dongeun Huh, Nicholas Ieronimakis, Edward J Kelly, Svetlana Lutsenko, Robert M Stroud, Jacqueline B Tiley, Jia Yang, Xujia Zhou, Hao Zhu, Rajini Rao, Kathleen M Giacomini, Lauren M Aleksunes   +16 more
wiley   +1 more source

Selective γ8 transmembrane α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor regulatory protein negative allosteric modulators: Efficacy in preclinical antiseizure models

Epilepsia, EarlyView.
Abstract Objective RAP‐219, a potent selective negative allosteric modulator (NAM) of α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPAR) associated with γ8 transmembrane AMPAR regulatory protein (TARPγ8), is in phase 3 development for refractory focal epilepsy. This study was undertaken to assess efficacy and motor function following
Jose A. Matta, Brock T. Shireman, Laurie P. Volak, Michael P. Maher, Michael K. Ameriks, David Bredt   +5 more
wiley   +1 more source