Results 51 to 60 of about 7,734 (200)

Integrating New Approach Methodologies to Address Environmental Pancreatic Toxicity and Metabolic Disorders

Biology
Advancing our understanding of pancreatic toxicity and metabolic disorders caused by environmental exposures requires innovative approaches. The pancreas, a vital organ for glucose regulation, is increasingly recognized as a target of harm from ...
Yue Ge
doaj   +1 more source

Provision of medical assistance to military personnel and civilians in clinical institutions of the National Academy of Medical Sciences of Ukraine during the ATO/JFO

Medičnì Perspektivi, 2020
Purpose – analysis and generalization of the experience of the National Academy of Medical Sciences (NAMS) of Ukraine and its subordinate research institutions, with clinical units in their structure, on the provision of highly specialized medical care ...
V. I. Tsymbalyuk, I. A. Lurin, V. O. Zhakhovskiy, V. G. Livinskiy, A. V. Shvets   +4 more
doaj   +1 more source

Bisphenol Analog‐Induced Cytotoxicity: Unraveling Endoplasmic Reticulum (ER) Stress and Apoptotic Pathways

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is increasingly replaced by structural analogs, yet their safety remains insufficiently characterized. This study investigated whether BPA and selected analogs, bisphenol AF (BPAF), bisphenol AP (BPAP), bisphenol P (BPP), and bisphenol E (BPE), induce cytotoxicity through activation of endoplasmic reticulum (ER) stress and ...
Rafia Afroze Rifa, Ramon Lavado
wiley   +1 more source

Highlighting best practices to advance next-generation risk assessment of cosmetic ingredients

NAM Journal
Public expectations and regulatory demands have driven a paradigm shift in cosmetic ingredient safety assessment. Next-generation risk assessment (NGRA) and new approach methodologies (NAMs) provide an opportunity to implement alternative procedures ...
Eric Vaillancourt, Alaa Afdal Mohamed, Jay Ansell, Takao Ashikaga, Ahmed Ayad, Hadeel Ayman, Marize Valadares Campos, Han-Sheng Chien, Arianna Giusti, Masato Hatao, Frances Hill, Abeer Khattab, Reinhard Kreiling, Ah Young Lee, Miao Li, Pinpin Lin, Yen-Chun Lin, Victor Mencarelli, Stanley Milstein, Beta P. Montemayor, Carolina Motter Catarino, Rawda Negm, Gladys Ouédraogo, Eun Jae Park, Mustafa Varçin, Tzu-Yi Yang, Yu Janet Zang, Matthew Philip Dent   +27 more
doaj   +1 more source

Brain MR image segmentation using NAMS in pseudo-color

Computer Assisted Surgery, 2017
Image segmentation plays a crucial role in various biomedical applications. In general, the segmentation of brain Magnetic Resonance (MR) images is mainly used to represent the image with several homogeneous regions instead of pixels for surgical ...
Hua Li, Chuanbo Chen, Shaohong Fang, Shengrong Zhao   +3 more
doaj   +1 more source

High‐Content Screening Comparison of 1R6F Cigarette Smoke Extract and Selected Heated Tobacco and Electronic Vapour Product Aerosol Extracts in Endothelial and Bronchial Epithelial Cell Models

Journal of Applied Toxicology, EarlyView.
ABSTRACT Cigarettes induce oxidative stress and DNA damage, processes that contribute to cardiovascular and pulmonary disease. High content screening (HCS) is an increasingly valuable tool for comparative toxicology because it enables simultaneous quantification of multiple mechanistic endpoints at single‐cell resolution. In this study, HCS was used to
Edgar Trelles Sticken, Konstantinos Papikinos, Fiona Chapman, Roman Wieczorek, Sarah Jean Pour, Torge Evenburg, Sandra Otte, Tiandan Wu, Liam Simms, Matthew Stevenson   +9 more
wiley   +1 more source

Balancing chemical safety and animal welfare considerations in the application of new approach methodologies for chemical safety assessment

NAM Journal
Despite some considerable advancement in developing different forms of new approach methodologies (NAMs) to assess the risk of chemicals, there is still limited progress in their application for regulatory purposes in the European Union (EU).
Aleksandra Čavoški, Laura Holden, Leonie Mueller, Robert Lee   +3 more
doaj   +1 more source

Prey detection by the predator remains constant across prey densities: evidence from a field experiment in the Arctic tundra

Oikos, EarlyView.
The functional response describes how predator acquisition rates change with prey availability and integrates behavioural processes that occur during predator–prey encounters. Among these processes, prey detection represents a critical yet often overlooked component that can directly influence population dynamics. Variation in detection probability has
Matthieu Weiss‐ Blais, Andréanne Beardsell, Pierre Legagneux, Joël Bêty   +3 more
wiley   +1 more source

Altermagnetismus und neue Chancen für die Spintronik: Das Beste aus zwei Welten

Physik in unserer Zeit, EarlyView.
Sie gelten als die Zukunft der Spintronik: Altermagnete kombinieren die Vorzüge von Ferro‐ und Antiferromagneten, was lange Zeit als physikalisch unvereinbar galt. Der Grund für dieses Potential liegt in ihrer spezifischen Symmetrie. Zusammenfassung Klassisch werden magnetische Materialien in Ferromagnete (parallele Spins) und Antiferromagnete ...
Sonka Reimers, Martin Jourdan, Mathias Kläui   +2 more
wiley   +1 more source

A regulatory perspective on the applicability of NAMs in genotoxicity and carcinogenicity assessment in EU: current practices and future directions

Environment International
New Approach Methodologies (NAMs) are gaining significant momentum globally to reduce animal testing and enhance the efficiency and human relevance of chemical safety assessment.
Cecilia Bossa, Silvia Alivernini, Cristina Andreoli, Gabriele Aquilina, Leonello Attias, Emilio Benfenati, Maria Dusinska, Naouale El Yamani, Henriqueta Louro, Francesca Marcon, Giuseppa Raitano, Elise Rundén-Pran, Maria Teresa Russo, Maria João Silva, Chiara Laura Battistelli   +14 more
doaj   +1 more source