Results 41 to 50 of about 7,734 (200)

Paediatric developmental safety and the ICH E11A extrapolation of safety

British Journal of Clinical Pharmacology, EarlyView.
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Rebecca Racz, Sherbet Samuels, Dionna J. Green, Lynne P. Yao   +6 more
wiley   +1 more source

Comparing Transcriptomic Responses to Chemicals Across Six Species Using the EcoToxChip RNASeq Database

Environmental Toxicology and Chemistry, EarlyView.
Abstract The EcoToxChip project includes RNA‐sequencing data from experiments involving model (Japanese quail, fathead minnow, African clawed frog) and ecological (double‐crested cormorant, rainbow trout, northern leopard frog) species at multiple life stages (whole embryo and adult) exposed to eight chemicals of environmental concern known to perturb ...
Krittika Mittal, Jessica Ewald, Doug Crump, Jessica Head, Markus Hecker, Natacha Hogan, Jianguo Xia, Niladri Basu   +7 more
wiley   +1 more source

Cytotoxicity of 19 Pesticides in Rainbow Trout Gill, Liver, and Intestinal Cell Lines

Environmental Toxicology and Chemistry, EarlyView.
Abstract The rainbow trout gill cell line (RTgill‐W1), via test guideline 249 of the Organisation for Economic Co‐operation and Development, has been established as a promising New Approach Methodology, although to advance confidence in the method more case studies are needed that: 1) expand our understanding of applicability domains (chemicals with ...
Sophie Emberley‐Korkmaz, Krittika Mittal, Na'im Temlock, Jessica Head, Niladri Basu   +4 more
wiley   +1 more source

Complement-ARIE: Catalyzing the development and adoption of new approach methodologies

NAM Journal
New approach methodologies (NAMs) are proving to be invaluable tools in basic and clinical research to better understand human health and disease, elucidate mechanisms, and study the efficacy and toxicity of novel therapeutics that can improve upon and ...
Kristifor Sunderic, Andrew M. Wright, Nicole Kleinstreuer, Victoria Ledbetter, Katelynn A. Milora, Christine Happel, Daniel Shaughnessy, Chariz P. Johnstone, Daniel Anthony Casco, Nikeya Macioce, Jacqui Marzec, Kristin Kano, Margaret J. Ochocinska, Danilo A. Tagle   +13 more
doaj   +1 more source

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

The effect of commonly used non-antibiotic medications on antimicrobial resistance development in Escherichia coli

npj Antimicrobials and Resistance
Antimicrobial resistance (AMR) poses a global threat to public health. While antibiotic overuse is a primary driver, emerging evidence suggests that non-antibiotic medications (NAMs) may also contribute.
Hanbiao Chen, Sylvia A. Sapula, John Turnidge, Henrietta Venter   +3 more
doaj   +1 more source

Panel discussions on the global regulatory acceptance and harmonisation of non-animal NAMs

NAM Journal
Two panel discussions on non-animal New Approach Methodologies (NAMs) in regulatory safety assessments were held as webinars. These webinars were initiated and hosted by the scientific committee Pro Anima with contributions from international experts in ...
Lilas Courtot, Ellen Fritsche, Nina Hobi, Nicole Kleinstreuer, Robert Lee, Surat Parvatam, Merel Ritskes-Hoitinga, Clive Roper, Carl Westmoreland, Emeline Gougeon   +9 more
doaj   +1 more source

Based on the Materials of IV Scientific Session of the Institute of Gastroenterology of the NAMS of Ukraine «New Technologies in Theoretical and Clinical Gastroenterology»

Gastroenterologìa, 2016
The article presents the materials of the IV scientific session of the Institute of gastroenterology of NAMS of Ukraine "New technologies in theoretical and clinical gastroenterology", which was held June 16-17, 2016 in the Dnipro by State institution ...
I.Yu. Skyrda, O.P. Halenko
doaj   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Emerging Human‐Based Research Technologies for Investigating the Pathomechanisms and Therapies for Vascular Diseases

iNew Medicine, EarlyView.
ABSTRACT It is estimated that a large proportion of drug candidates fail in human clinical trials, mainly because animal models cannot fully replicate human disease and because of differential responses to various medications between humans and animals.
Weiping Ding, Iqra Ilyas, Suowen Xu
wiley   +1 more source