Results 21 to 30 of about 308,373 (307)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Education for Sustainability – Are we Forgetting the Economic Dimension?

Irish Journal of Academic Practice
The world's economies face acute anthropocentric challenges. We are witnessing significant structural disruption, driven by an urgent need to redress a historical focus on unchecked economic growth and unequal access to resources, requiring seismic ...
Ozeias Rodrigues da Rocha, Daniel Kamphambale, Jon-Hans Coetzer, Cormac H. MacMahon, Lucia Morales   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Review: cell mechanisms in the control of inflammatory foundations of obesity and secondary metabolic disorders

SURE Journal: (Science Undergraduate Research Experience Journal)
Review: Obesity is a global threat to human health that is precipitating epidemically, with almost 2 billion adults categorised as overweight or obese in 2016.
Kristin Goldstone, Keelin Irwin, Ava O' Meara-Cushen, Cathy Brougham   +3 more
doaj   +1 more source

Non-Anthocyanin Compounds in Minority Red Grapevine Varieties Traditionally Cultivated in Galicia (Northwest Iberian Peninsula), Analysis of Flavanols, Flavonols, and Phenolic Acids

Plants, 2022
Non-anthocyanin compounds (NAN) such as flavonol, flavanol, and phenolic acids should be considered in the characterization of minority red grapevine varieties because these compounds are involved in copigmentation reactions and are potent antioxidants ...
Ángela Díaz-Fernández, Emilia Díaz-Losada, Anxo Vázquez-Arias, Anna Puig Pujol, Daniel Moreno Cardona, María Esperanza Valdés-Sánchez   +5 more
doaj   +1 more source

Application of Geomembrane on the Dam of Concrete Face in a Certain Hydropower Station Project [PDF]

E3S Web of Conferences, 2020
A certain hydropower station is a concrete face rockfill dam, with the dam height of 219 m. Because of various reasons, Composite geomembrane was added on the concrete face below the elevation of 382 m. A combined impermeable system composed of composite
Kai PENG, Yaolai LIU, Liangliang MA, Guohui WANG, Xiaoliang WANG, Juan HU   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Circular Pedagogy to Support Technological Universities Cultural Transformation

Irish Journal of Academic Practice
European countries need active and proactive educational systems assisted by models that can drive a cultural transformation, which supports sustainable socio-economic and environmental development.
Ivaylo Peev, Jon-Hans Coetzer, Nadia Barkoczi, Iulia Stefan, Todor Todorov, Patrick Flynn, Claudia Marian, Sonia Munteanu, Lia Pop, Lucia Morales   +9 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Estasyon Meteyo nan Jaden: Gid pou Enstalasyon ak Antretyen

EDIS, 2019
Si w se yon kiltivatè ki vle obsève kondisyon meteyo yo pou ka asire w jaden w yo ap grandi nan yon  bon anviwonman, ou sou bon chemen an. Chanjman meteyo yo jwe yon gwo wòl nan siksè oswa echèk aktivite agrikòl yo, kiltivatè yo rekonèt sa a. Kòm kounye
Caroline G. Staub, William Eisenstadt, William Blanc, Nicole Monval, Clyde W. Fraisse, William Lusher, George Braun, Lee Staudt   +7 more
doaj   +3 more sources