Results 41 to 50 of about 308,373 (307)
Mae Nan Ellingson Interview, July 25, 2022 [PDF]
, 2022 Mae Nan Ellingson discusses her early life and work at her family’s drive-in restaurant in Texas. Mae Nan talks about her interest in history and political science that began in high school in Texas.
Ellingson, Mae Nan
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Te Kaharoa, 2021 This paper explores some of the many stories that my grandmother, Rēpora Marion Brown—Nan, told me when growing up and throughout my adult life. Nan was born at Waiōhau in 1940 and died at her home at Murupara in 2017. Nan was married to Papa— Edward Tapuirikawa Brown. Nan and Papa lived on Kōwhai Avenue in Murupara.
openaire +2 more sources
, 2006 Nan arrived in Darwin on the 4th February 1954 and started teaching infants at Darwin Higher Primary school. Through the next decades she taught at Darwin Primary, Parap, Jabiru, Larrakeyah and Anula. Nan had not been in Darwin for very long when she met
Bell, Nan
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FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
02.14.1921 Nan to Bert.1 [PDF]
, 1921 Nan whishes Bert and Henrietta a happy and prosperous life in “the good old USA”
Bidault, Nan
core +1 more source