Results 31 to 40 of about 308,373 (307)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Anatomical, chemical and endophytic fungal diversity of a Qi-Nan clone of Aquilaria sinensis (Lour.) Spreng with different induction times

Frontiers in Plant Science
Recently, some new Qi-Nan clones of Aquilaria sinensis (Lour.) Spreng which intensively produces high-quality agarwood have been identified and propagated through grafting techniques. Previous studies have primarily focused on ordinary A.
Xiaofei Li, Xiaofei Li, Xiaoying Fang, Zhiyi Cui, Zhou Hong, Xiaojin Liu, Gaiyun Li, Houzhen Hu, Daping Xu   +8 more
doaj   +1 more source

The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation.

PLoS ONE, 2019
Krüppel-like factor 1 (KLF1) is an essential transcription factor for erythroid development, as demonstrated by Klf1 knockout mice which die around E14 due to severe anemia. In humans, >140 KLF1 variants, causing different erythroid phenotypes, have been
Ileana Cantú, Harmen J G van de Werken, Nynke Gillemans, Ralph Stadhouders, Steven Heshusius, Alex Maas, Fatemehsadat Esteghamat, Zeliha Ozgur, Wilfred F J van IJcken, Frank Grosveld, Marieke von Lindern, Sjaak Philipsen, Thamar B van Dijk   +12 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Analysis of cultivation characteristics and active components of the new strain of antler-shape Ganoderma lucidum with juncao

四川大学学报. 自然科学版, 2020
In order to expand the cultivation substrate of Ganoderma lucidum and apply the new strain, the method of cultivating Ganoderma lucidum with juncao and analyzing its protein, amino acid, polysaccharide and triterpene was used.
LIN Xing-Sheng, LIN Zhang-Xi, LIN Hui, LIN Dong-Mei, LUO Hai-Ling, HU Ying-Ping   +5 more
doaj  

A Note on Derivative of Sine Series with Square Root

Abstract and Applied Analysis, 2021
Chaundy and Jolliffe proved that if an is a nonnegative, nonincreasing real sequence, then series ∑ansinnx converges uniformly if and only if nan⟶0. The purpose of this paper is to show that if nan is nonincreasing and nan⟶0, then the series fx=∑ansinnx ...
Sergiusz Kęska
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PERANCANGAN DAN IMPLEMENTASI SISTEM PENUNJANG KEPUTUSAN UNTUK MENDUKUNG PROSES PENYELEKSIAN SISWA BARU PADA SMAN 1 NAN SABARIS

Jurnal Teknoif Teknik Informatika Institut Teknologi Padang, 2016
SMAN 1 Nan Sabaris merupakan salah satu instansi pendidikan di lingkungan Pemerintahan yang bertugas untuk menyelenggarakan pendidikan. Untuk kemudahan kegiatan penyeleksian siswa baru pada SMAN 1 Nan Sabaris dibutuhkan sebuah sistem pendukung keputusan ...
Alhamidi
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A Conversation with Nan Laird

Statistical Science, 2015
Nan McKenzie Laird is the Harvey V. Fineberg Professor of Biostatistics at the Harvard T. H. Chan School of Public Health. She has made fundamental contributions to statistical methods for longitudinal data analysis, missing data and meta-analysis. In addition, she is widely known for her work in statistical genetics and in statistical methods for ...
openaire   +4 more sources