Results 51 to 60 of about 159,461 (291)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Effect of flavor characteristics and salt reduction and flavor enhancement of three edible fungi by Nano-pulverization

Shipin yu jixie
Objective: This study aimed to optimize the processing technology of edible fungi and evaluate its application potential as flavoring agents in the food industry. Methods: The content of non-volatile flavor components of the samples was determined by ion
BAN Xinrong, YANG Yan, LI Wen, WU Di, ZHANG Zhong, CHEN Wanchao, LI Jingjun   +6 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Differential Expression of Serum Proteins in Rats with Allergic Asthma: A Study Based on the Nanoliter Two-Dimensional Liquid Chromatography Technique

Canadian Respiratory Journal, 2017
Objective. To investigate the pathogenesis of allergic asthma via the nanoliter two-dimensional liquid chromatography (nano-2D-LC) technique. Method. 24 Wistar rats were randomized into 3 groups: the blank-control group (A), the restrained group (B), and
Xingke Yan, Ao Zhang, Lu Yu, Cheng Chen, Haifu Cui   +4 more
doaj   +1 more source

Standard flow liquid chromatography for shotgun proteomics in bioenergy research

Frontiers in Bioengineering and Biotechnology, 2015
Over the past ten years the bioenergy and biofuels field has realized significant achievements that have encouraged many follow on efforts centered on biosynthetic production of fuel-like compounds.
Susana M. González Fernández-Niño, A. Michelle Smith-Moritz, Leanne Jade G. Chan, Paul D. Adams, Paul D. Adams, Joshua L Heazlewood, Joshua L Heazlewood, Christopher J. Petzold   +7 more
doaj   +1 more source

Molecular composition of particulate matter emissions from dung and brushwood burning household cookstoves in Haryana, India [PDF]

, 2018
Emissions of airborne particles from biomass burning are a significant source of black carbon (BC) and brown carbon (BrC) in rural areas of developing countries where biomass is the predominant energy source for cooking and heating.
Arora, NK, Blake, DR, Edwards, RD, Fleming, LT, Laskin, A, Laskin, J, Lin, P, Meinardi, S, Nizkorodov, SA, Pillarisetti, A, Smith, KR, Weltman, R, Yadav, A   +12 more
core   +2 more sources

Highly Sensitive Electrochemical Biosensor Based on Hairy Particles with Controllable High Enzyme Loading and Activity

Advanced Functional Materials, EarlyView.
For the first time, a highly sensitive electrochemical biosensor based on SiO2‐based hairy particles with a grafted PDMAEMA polymer brush containing a quantifiable and large amount of immobilized Laccase is reported. The fabricated biosensor exhibits a sensitivity of 0.14 A·m⁻¹, a limit of detection (LOD) of 0.1 µm, and a detection range of 0.3–750 µm,
Pavel Milkin, Anila Antony, Hongtao Cai, Antonia Debevc, Ceyda Topal, Anne Linhardt, Alla Synytska, Leonid Ionov   +7 more
wiley   +1 more source

Development of Wall-Coated Open Tubular Columns and Their Application to Nano Liquid Chromatography Coupled to Tandem Mass Spectrometry

Molecules, 2023
This work presents a study on the application of wall open tubular column (WCOT) in liquid chromatography coupled with tandem mass spectrometry. Each process step reports the column preparation method in detail, subdivided into column pretreatment ...
Natalia G. P. Santos, Deyber A. V. Medina, Fernando M. Lanças   +2 more
doaj   +1 more source

Hydrogen Evolution on Hydrophobic Aligned Carbon Nanotube Arrays [PDF]

, 2009
We investigate for the first time hydrophobic carbon nanotube-based electrochemical cells as an alternative solution to hydrogen sorting. We show that the electrically conducting surface of the nanotube arrays can be used as a cathode for hydrogen ...
Daraio, Chiara, Giri, Jyotsnendu, Misra, Abha   +2 more
core   +1 more source