Results 31 to 40 of about 1,581 (100)

392 Adjuvants for the potentiation of the activity of β-lactam antibiotics against methicillin-resistant Staphylococcus aureus

Journal of Clinical and Translational Science
Objectives/Goals: Methicillin-resistant Staphylococcus aureus (MRSA) is a human bacterial pathogen and is classified as a serious threat. MRSA has become resistant to most B-lactam antibiotics (penicillins and cephalosporins).
Caitlyn Thomas, Caitlyn A Thomas, Choon Kim, Amr M. El-Araby, Biruk T. Birhanu, Shahriar Mobashery, Mayland Chang   +6 more
doaj   +1 more source

Engineering of the Promiscuous Acyltransferase EstCE1 for the Synthesis of the Natural Antioxidant Tiliroside in Bulk Water

ChemCatChem, Volume 18, Issue 14, 29 July 2026.
Variants of the promiscuous acyltransferase EstCE1 enable efficient and regioselective synthesis of tiliroside from astragalin and vinyl coumarate in aqueous solution ABSTRACT Tiliroside is a bioactive natural flavonoid derivative with promising antioxidant properties and potential applications in the food, cosmetics, and pharmaceutical industries ...
Benjamin Baumert, Christoffel P. S. Badenhorst, Karsten Siems, Uwe T. Bornscheuer   +3 more
wiley   +1 more source

Controlled Functionalization Strategy of Proteins Preserves their Structural Integrity While Binding to Nanocarriers

Advanced Materials Interfaces
The use of proteins as targeting agents often requires their chemical modification for their efficient attachment to a given surface. However, no control over the protein integrity and functionality has been demonstrated to date.
Ana Mateos‐Maroto, Meiyu Gai, Maximilian Brückner, Volker Mailänder, Svenja Morsbach, Katharina Landfester   +5 more
doaj   +1 more source

Integrative in silico and experimental identification of non-covalent UBE2N inhibitors enhancing PARP inhibitor sensitivity

European Journal of Medicinal Chemistry Reports
UBE2N, an E2 ubiquitin-conjugating enzyme, has emerged as a promising therapeutic target in oncology due to its critical roles in DNA damage repair and NF-κB signalling.
Côme Ghadi, Shafi Ullah Khan, Léonie Ibazizene, Florian Schwalen, Charline Kieffer, Peggy Suzanne, Julie Jaouen, Hassiba Bouafia, Xavier Thuru, Marie Cornu, Cedric Lecoutey, Matthieu Meryet-Figuiere, Anne Sophie Voisin-Chiret, Louis-Bastien Weiswald, Jana Sopkova-de Oliveira Santos   +14 more
doaj   +1 more source

Mass spectrometry-guided discovery of novel GCPII inhibitor scaffolds

Frontiers in Pharmacology
IntroductionThere is an unmet need for therapeutics with a novel mechanism to address Q9 symptoms associated with conditions where aberrant glutamatergic neurotransmission is presumed pathogenic.
Robyn Wiseman, Robyn Wiseman, Ajit G. Thomas, John Janiszewski, Nate Hoxie, Chae Bin Lee, Ying Wu, Takashi Tsukamoto, Takashi Tsukamoto, Takashi Tsukamoto, Lin Ye, Michael Ronzetti, Jonathan H. Shrimp, Davina Adderley, Ganesha Rai, Rana Rais, Rana Rais, Rana Rais, Jesse Alt, Matthew D. Hall, Xin Hu, Stephen C. Kales, Barbara S. Slusher, Barbara S. Slusher, Barbara S. Slusher, Barbara S. Slusher, Barbara S. Slusher, Barbara S. Slusher, Barbara S. Slusher, Barbara S. Slusher   +29 more
doaj   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, Volume 13, Issue 33, 15 June 2026.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Pseudomonas aeruginosa MipA-MipB envelope proteins act as new sensors of polymyxins

mBio
Due to the rising incidence of antibiotic-resistant infections, the last-line antibiotics, polymyxins, have resurged in the clinics in parallel with new bacterial strategies of escape.
Manon Janet-Maitre, Viviana Job, Maxime Bour, Mylène Robert-Genthon, Sabine Brugière, Pauline Triponney, David Cobessi, Yohann Couté, Katy Jeannot, Ina Attrée   +9 more
doaj   +1 more source

PERSPECTIVE: organelle positioning as a principle of metabolic regulation and stress tolerance

The Plant Journal, Volume 126, Issue 6, June 2026.
SUMMARY Plants have evolved elaborate acclimation strategies to withstand adverse environments, involving all levels of their function and organization. While macroscopic movements through differential growth that enable the physical re‐shaping and ‐positioning of organs have been a major field of study, the highly active dynamics of cell organelles ...
Alisdair R. Fernie, Guillaume Decros, Jan Multhoff, Jana Sippel, Jan‐Ole Niemeier, Pedro Barreto, Arun Sampathkumar, Uwe Sonnewald, Markus Schwarzländer   +8 more
wiley   +1 more source

Identification of 2‐Substituted‐3‐Hydroxy‐2,3‐Dihydroquinazolin‐4(1H) Ones as Cell‐Active Inhibitors of KDM4A Lysine Demethylase

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
A novel 3‐hydroxy‐2,3‐dihydroquinazolinone scaffold is identified as a cell‐active KDM4A inhibitor through an orthogonal screening cascade minimizing assay interference. Integrated biochemical, biophysical, and proteomic validation reveals compound 6i as a bona fide binder that increases H3K9 methylation in cells, highlighting both a promising ...
Alessandra Feoli, Amodio Luca Balzano, Ida Pacilio, Alessandra Cipriano, Roman Belle, Giacomo Pepe, Manuela Giovanna Basilicata, Pietro Campiglia, Fabrizio Micheli, Akane Kawamura, Ciro Milite, Sabrina Castellano, Axel Imhof, Gianluca Sbardella   +13 more
wiley   +1 more source

Novel GH115 xylan α‐1,2‐glucuronidases with distinct preferences for xylan‐derived oligomers and polymers

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Natural polymers are promising sustainable materials for diverse applications. Xylans, major components of hemicellulose, exhibit origin‐dependent substitution patterns that determine their physicochemical properties. Targeted enzymatic modification of these substituents offers a mild and precise approach for tailoring the polymer's ...
Savvina Leontakianakou, Simone Balzer Le, Anders Sundin, Andrius Jasilionis, Giang‐Son Nguyen, Anna Nordborg, Lalitha D. Gottumukkala, Carl Grey, Anna Sofia Lewin, Eva Nordberg Karlsson   +9 more
wiley   +1 more source