Results 91 to 100 of about 69,654 (255)

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

, 2017
Fakhar ud Din,1,* Waqar Aman,2,* Izhar Ullah,3 Omer Salman Qureshi,4 Omer Mustapha,5 Shumaila Shafique,6 Alam Zeb7 1Department of Pharmacy, Quaid-i-Azam University, Islamabad, 2Department of Pharmacy, Kohat University of Science and Technology, Kohat ...
Qureshi OS, Shafique S, Din FU, Aman W, Mustapha O, Ullah I, Zeb A   +6 more
core  

Based on polysaccharide nanocarriers: mechanisms of bioactivity potentiation and latest research progress

Frontiers in Biomaterials Science
As nanoscale drug-delivery systems constructed from natural polysaccharides, polysaccharide nanocarriers combine the inherent biocompatibility, biodegradability, and diverse bioactivities of polysaccharides with the unique size effects and functional ...
Juan Du, Chuanli Jin, Ze Dang, Ruian Ma, Chen Chen, Qinglin Bian, Peng Lv, Yanhu Ji, Weicheng Gao, Shunhui Liu   +9 more
doaj   +1 more source

Polymer-Based Nanocarriers for Co-Delivery and Combination of Diverse Therapies against Cancers

Nanomaterials, 2018
Cancer gives rise to an enormous number of deaths worldwide nowadays. Therefore, it is in urgent need to develop new therapies, among which combined therapies including photothermal therapy (PTT) and chemotherapy (CHT) using polymer-based nanocarriers ...
Guowen Yan, Aihua Li, Aitang Zhang, Yong Sun, Jingquan Liu   +4 more
doaj   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

New targeting agent for the selective drug delivery of nanocarriers for treating neuroblastoma

, 2015
RESEARCH ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí) RESEARCH ID M-3316-2014 (Antonio Salinas Sánchez) ORCID 0000-0002-8408-3389 (Antonio Salinas Sánchez) ORCID 0000-0003-2065-0417 (Gonzalo Villaverde Cantizano ...
Melen, Gustavo J., Ramirez, Manuel, Alfranc, Arantzazu, Villaverde Cantizano, Gonzalo, Vallet Regí, María Dulce Nombre, Baeza, Alejandro, Alfranca, Arantzazu   +6 more
core   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

Nanocarrier-Based Transdermal Drug Delivery Systems for Dermatological Therapy

Pharmaceutics
Dermatoses are among the most prevalent non-fatal conditions worldwide. Given this context, it is imperative to introduce safe and effective dermatological treatments to address the diverse needs and concerns of individuals.
Yunxiang Kang, Sunxin Zhang, Guoqi Wang, Ziwei Yan, Guyuan Wu, Lu Tang, Wei Wang   +6 more
doaj   +1 more source

Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs

Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley   +1 more source