Results 71 to 80 of about 69,654 (255)

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Electrostatic attraction-directed membrane anchoring as a universal tool to enhance nanocarrier uptake into drug-resistant cancer cells

Nano Research
The development of nanomedicine that can be efficiently internalized by drug-resistant cancer cells still presents a daunting challenge due to the low uptake capacity caused by various drug resistance-related factors on the cell membrane.
Qixiao Guan, Rong Chen, Zhengtao Tian, Peipei Zhang, Lingshan Liu, Meng Cheng, Yirong Zeng, Daikun Wu, Min Zhou, Hongjing Dou   +9 more
doaj   +1 more source

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

Advanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han, Yao Zhao, Chengbo Yang, Miao Niu, Jun Dai, Quanxin Ning, Kai Xiao, Jinzheng Liang, Wensheng Zhang, Liang Wang, Dan Shao, Dongsong Li   +11 more
wiley   +1 more source

Nanocarriers based on chitosan derivatives for siRNA delivery

, 2008
Nanocarriers based on chitosan derivatives for siRNA delivery. Content: 1.RNAimechanism 2.Barriers & Solutions for siRNAdelivery 3.Chitosannanoparticlesfor targeted siRNAdelivery 4.Chitosanmicelles for targeted ...
刘袖洞, 马小军
core  

Nanocarriers in neurodegenerative disorders: therapeutic hopes and hypes

Due to the lack of secure, efficient, and patient-friendly therapies for neurodegenerative disorders, there is a rising demand for innovative approaches.

core   +1 more source

Lipid Nanocarriers for Intracellular Delivery

, 2018
Recent trends in drug delivery indicate a growing trend to utilize nanotechnology to target diseased tissues with minimal adverse effects. However, in such cases, the biggest challenge encountered by the formulator is the intracellular delivery of the ...
Divya Suares, Vivek Dhawan, Clara Bernard Fernandes   +2 more
core   +1 more source

Genetically engineered nanocarriers for drug delivery

, 2014
Pu Shi, Joshua A Gustafson, J Andrew MacKayDepartment of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, USAAbstract: Cytotoxicity, low water solubility, rapid clearance from circulation, and off-target side ...
Shi P, MacKay JA, Gustafson JA
core  

Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects on a blood–brain barrier model

Fluids and Barriers of the CNS
Background Targeting the blood–brain barrier (BBB) is a key step for effective brain delivery of nanocarriers. We have previously discovered that combinations of BBB nutrient transporter ligands alanine and glutathione (A-GSH), increase the permeability ...
Mária Mészáros, Thi Ha My Phan, Judit P. Vigh, Gergő Porkoláb, Anna Kocsis, Anikó Szecskó, Emese K. Páli, Nárcisz M. Cser, Tamás F. Polgár, Gábor Kecskeméti, Fruzsina R. Walter, Jens C. Schwamborn, Tamás Janáky, Jeng-Shiung Jan, Szilvia Veszelka, Mária A. Deli   +15 more
doaj   +1 more source

Interference of ATP‐Binding Cassette Transporter by Functional Nano‐Delivery System for High Efficiency Management of Insecticide‐Resistant Nilaparvata lugens

Advanced Science, EarlyView.
A ZIF‐90 nanocarrier delivers dinotefuran and suppresses NlABCG3 and NlABCH1 in resistant Nilaparvata lugens. This system combines pH/ATP‐triggered release with enhanced foliar retention, improving efficacy while sparing honeybees and promoting rice growth, offering a promising resistance‐breaking strategy.
Chengshuai He, Hejun Ren, Shuo Zhang, Jikang Cheng, Hui Zhang, Jiao Liu, Sijie Wang, Congfen Gao, Yanchao Zhang, Yunhao Gao   +9 more
wiley   +1 more source

In Situ Programmable Modulation of Hydrogel Stiffness for Stage‐Adaptive Bone Regeneration

Advanced Science, EarlyView.
Near‐infrared (NIR) irradiation triggers Ca2+ release from thermoresponsive nanocarriers, enabling in situ stiffening of an adaptive hydrogel from a soft to a stiff state, thereby sequentially supporting mesenchymal stromal cell stemness and osteogenic differentiation for stage‐adaptive bone regeneration.
Yuxin Yang, Fan Yang, Lu Wang, Zongtai Li, Weichang Li, Xinchun Zhang   +5 more
wiley   +1 more source