Results 41 to 50 of about 89,027 (290)

Chitosan Based MicroRNA Nanocarriers

Pharmaceuticals, 2022
Vectorization of microRNAs has shown to be a smart approach for their potential delivery to treat many diseases (i.e., cancer, osteopathy, vascular, and infectious diseases). However, there are barriers to genetic in vivo delivery regarding stability, targeting, specificity, and internalization.
Hussein H. Genedy, Thierry Delair, Alexandra Montembault   +2 more
openaire   +4 more sources

Semi-crystalline block copolymer bicontinuous nanospheres for thermoresponsive controlled release [PDF]

, 2014
We demonstrate the controlled release of pyrene, as a model hydrophobic molecule, from self-assembled bicontinuous nanospheres formed from an amphiphilic block copolymer.
Abraham, Andersson, Boyd, Bunjes, Costa, De Kee, Dong, Fu, George, Guo, Hempel, Higuchi, Hocine, Kedar, Korsmeyer, Langenbucher, McKenzie, McKenzie, McKenzie, Modi, O'Leary, Rizwan, Rösler, Sanson, Sanson, Schwarz, Spicer, Street, Varelas, Washington, Washington, Wei, Weibull, Zambito   +33 more
core   +3 more sources

Polymeric nanocarriers as stimuli-responsive systems for targeted tumor (cancer) therapy: Recent advances in drug delivery

Saudi Pharmaceutical Journal, 2020
In the last decade, considerable attention has been devoted to the use of biodegradable polymeric materials as potential drug delivery carriers. However, bioavailability and drug release at the disease site remain uncontrollable even with the use of ...
Mosa Alsehli
doaj   +1 more source

Surface Modification of Porous Polyethylene Implants with an Albumin-Based Nanocarrier-Release System

Biomedicines, 2021
Background: Porous polyethylene (PPE) implants are used for the reconstruction of tissue defects but have a risk of rejection in case of insufficient ingrowth into the host tissue.
Jonas Eckrich, Niklas Hoormann, Erik Kersten, Keti Piradashvili, Frederik R. Wurm, Martin Heller, Sven Becker, Toni Anusic, Juergen Brieger, Sebastian Strieth   +9 more
doaj   +1 more source

Application of crossflow ultrafiltration for scaling up the purification of a recombinant ferritin [PDF]

, 2019
Ferritin proteins are taking center stage as smart nanocarriers for drug delivery due to their hollow cage-like structures and their unique 24-meric assembly.
Boffi, A., Bonamore, A., Ghirga, F., Macone, A., Palombarini, F.   +4 more
core   +1 more source

Superparamagnetic Poly (3-hydroxybutyrate-co-3 hydroxyvalerate) (PHBV) nanoparticles for biomedical applications [PDF]

, 2013
Indexación: ScieloBackground: The progress in material science and the recent advances in biodegradable/biocompatible polymers and magnetic iron oxide nanoparticles have led to develop innovative diagnostic and therapeutic strategies for diseases based ...
Altbir, Dora, Denardin, Juliano C., Escobar, Roberto A., Gutiérrez, Marlen, Morales, Francisco, Velasquez, Luis, Vilos, Cristian   +6 more
core   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Mitochondria-Targeting and ROS-Responsive Nanocarriers via Amphiphilic TPP-PEG-TK-Ce6 for Nanoenabled Photodynamic Therapy

Advances in Polymer Technology, 2022
Designing targeted-delivering and stimuli-responsive nanocarriers for photodynamic therapy (PDT) is an appealing method, especially, targeting delivery of photosensitizers to mitochondria as the most sensitive cellular organelles to reactive oxygen ...
Yangjian Wang, Junshui Zheng, Jian Lin, Kai Ye, Peng Wei   +4 more
doaj   +1 more source

Recent Progress in Transdermal Nanocarriers and Their Surface Modifications

Molecules, 2021
Transdermal drug delivery system (TDDS) is an attractive method for drug delivery with convenient application, less first-pass effect, and fewer systemic side effects.
Zhixi Yu, Xinxian Meng, Shunuo Zhang, Yunsheng Chen, Zheng Zhang, Yixin Zhang   +5 more
doaj   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source