Results 141 to 150 of about 14,638 (259)

Molecular Machine‐Driven Fluorogenic Probes for Motion–Signal Conversion and Hydrophilicity Retention in Live‐Cell Nanoscopy

Aggregate, Volume 7, Issue 10, October 2026.
A hydrophilicity‐retention strategy for developing fluorogenic probes by conjugating malachite green (as the molecular motion switch) with a spirocyclization‐free rhodamine (as the signal module) was developed for nanoscopic imaging of mitochondrial cristae structures and dynamics in living cells.
Yuan Luo, Lili Du, Xing Yang, Ke Liu, Chunbai Xiang, Yuanyuan Wang, Daoyong Jiang, Zihan Wu, Xiang‐Yang Lou, Xiaokang Zhang, Jiajie Diao, Xiaoshuai Huang, Ping Gong, Ben Zhong Tang, Lintao Cai, Pengfei Zhang   +15 more
wiley   +1 more source

Preparation and Characterization of Ocimum basilicum Extract‐Loaded Niosomes and Evaluation of Their Cytotoxic and Pro‐Apoptotic Potential in SKOV3 Ovarian Cancer Cells

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Ocimum basilicum extract was successfully encapsulated in niosomal nanocarriers, resulting in a sustained‐release formulation with favorable physicochemical characteristics. In SKOV3 ovarian cancer cells, the extract‐loaded niosomes showed enhanced cytotoxicity compared with the free extract and blank niosomes.
Zahra Mousavi, Mahsa Kavousi, Mahnaz Farahmand   +2 more
wiley   +1 more source

A Novel Nanoantibiotic Formulation With Magnetic and Targeting Potential: Ampicillin‐Conjugated L‐glu–Fe3O4 NPs

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
A novel nanoformulation consisting of ampicillin (Amp), l‐glutamic acid (l‐glu), and iron oxide nanoparticles was prepared. l‐glu–Fe3O4–Amp NPs exhibited a controlled drug release profile over a certain period of time. The antibacterial effectiveness of the formulation was proven by agar well diffusion and the LIVE/DEAD BacLight fluorescent assays. The
Mehmet Demirel, Ozlem Baris, Mesut Taskin, Seyda Albayrak, Ferhunde Aysin, Azada Aliyeva, Buket Bakan   +6 more
wiley   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

Nanopriming and Nanocoating as a Next‐Generation Seed Treatment for Enhanced Plant Growth and Pathogen Resistance

Plant-Environment Interactions, Volume 7, Issue 5, October 2026.
ABSTRACT In pursuit of sustainable agriculture, current strategies continue to explore environmentally friendly inputs that promote plant development. Seed treatment is an ancient practice used to break seed dormancy and hasten germination. Although traditional seed treatments yield positive outcomes, the methods adopted raise concerns about the ...
Okainemen Godfrey Oribhabor, Damian C. Onwudiwe, Vanessa Nessner Kavamura, Jing Ge, Olubukola Oluranti Babalola   +4 more
wiley   +1 more source

Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models

Environmental Toxicology, Volume 41, Issue 10, Page 957-974, October 2026.
ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa, Analía Ale, Azael Francisco Silva Neto, Lorena De Mendonça Lucena, Marcelo Estrella Josende, Milena Ferreira de Lima, Rhayanny Kethylly Pereira Santos, Martín Federico Desimone, Priscila Gubert, José María Monserrat   +9 more
wiley   +1 more source

Targeting Ero1L by Parthenolide Alleviates Cellular Senescence and Fibrosis of Localized Scleroderma by Regulating Mitochondria‐Associated Endoplasmic Reticulum Membranes Stabilization

Aging Cell, Volume 25, Issue 10, October 2026.
PTL inhibits cell senescence and alleviates fibrosis of Los by regulating Ero1L‐mediated mitochondria‐associated endoplasmic reticulum membranes stabilization. ABSTRACT Mitochondrial dysfunction drives scleroderma pathogenesis. The mitochondria‐associated endoplasmic reticulum membrane (MAM) regulates mitochondrial function.
Fei Wang, Ru Xing, Meijuan Xie, Yimin Qin, Yunchao Zhang, Dan Cao, Gu He, Xiaoyan Lyu   +7 more
wiley   +1 more source

Recent advancements in colchicine derivatives: Exploring synthesis, activities, and nanoformulations for enhanced therapeutic efficacy

The multifaceted anti-cancer properties of colchicine make it a promising candidate for tumor treatment. However, its application has been limited by poor solubility, low bioavailability, and systemic toxicity.
Rubicondo, Marialucia, Ciardelli, Gianluca, Tuszynski, Jack A., Mattu, Clara   +3 more
core   +1 more source

Application of nanotherapy in cardiovascular diseases featuring novel pharmacological mechanisms and drug delivery strategies. [PDF]

Discov Nano
Yang J.
europepmc   +1 more source

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source