Results 41 to 50 of about 1,151 (165)

Exploring Nanocarriers as Treatment Modalities for Skin Cancer

Molecules, 2023
Cancer is a progressive disease of multi-factorial origin that has risen worldwide, probably due to changes in lifestyle, food intake, and environmental changes as some of the reasons.
Mohammad Adnan, Md. Habban Akhter, Obaid Afzal, Abdulmalik S. A. Altamimi, Irfan Ahmad, Manal A. Alossaimi, Mariusz Jaremko, Abdul-Hamid Emwas, Tanweer Haider, Md. Faheem Haider   +9 more
doaj   +1 more source

Surface‐Capped Protein Nanoparticles for Nonviral Gene Delivery

Advanced Materials, EarlyView.
ABSTRACT Developing simple, safe, and efficient nonviral delivery systems remains a significant challenge in bioengineering. Nanoparticles offer promising gene delivery capabilities with reduced toxicity; however, long‐standing challenges related to effective plasmid encapsulation and delivery exist.
Fjorela Xhyliu, Yao Yao, Yeongun Ko, Grant Grasman, Jeffery E. Raymond, Albert Chang, Yuxuan Deng, Grant Dominic, Michael Triebwasser, Joerg Lahann   +9 more
wiley   +1 more source

Polyphenols and Their Nanoformulations: Protective Effects against Human Diseases

Life, 2022
Polyphenols are the secondary metabolites synthesized by the plants as a part of defense machinery. Owing to their antioxidant, anti-inflammatory, anticancerous, antineoplastic, and immunomodulatory effects, natural polyphenols have been used for a long ...
Santosh Anand, Ramachandregowda Sowbhagya, Mohammad Azam Ansari, Mohammad A. Alzohairy, Mohammad N. Alomary, Asiyah I. Almalik, Wasim Ahmad, Takshashila Tripathi, Abozer Y. Elderdery   +8 more
doaj   +1 more source

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, EarlyView.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Interaction of curcumin nanoformulations with human plasma proteins and erythrocytes

International Journal of Nanomedicine, 2011
Murali Mohan Yallapu1, Mara C Ebeling1, Neeraj Chauhan1,3, Meena Jaggi1-3, Subhash C Chauhan1-31Cancer Biology Research Center, Sanford Research, 2Department of Obstetrics and Gynecology, 3Basic Biomedical Science Division, Sanford School of Medicine ...
Yallapu MM, Ebeling MC, Chauhan N, Jaggi M, Chauhan SC   +4 more
doaj  

Antibacterial activity of a berberine nanoformulation

Beilstein Journal of Nanotechnology, 2022
This study describes the preparation of berberine (BBR) in nanoformulation to enhance its solubility and increase its antibacterial effectiveness against hospital-acquired infections. BBR nanoparticles (BBR NPs) were formed by antisolvent precipitation (ASP) using glycerol as a safe organic solvent.
Hue Thi Nguyen, Tuyet Nhung Pham, Anh‐Tuan Le, Nguyễn Thanh Thủy, Tran Quang Huy, Thuy Thi Thu Nguyen   +5 more
openaire   +3 more sources

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

Nanomedicine in Oncocardiology: Contribution and Perspectives of Preclinical Studies

Frontiers in Cardiovascular Medicine, 2021
Cancer and cardiovascular diseases are the leading causes of death and morbidity worldwide. Strikingly, cardiovascular disorders are more common and more severe in cancer patients than in the general population, increasing incidence rates.
Gabriel Silva Marques Borges, Gabriel Silva Marques Borges, Eduardo Burgarelli Lages, Eduardo Burgarelli Lages, Pierre Sicard, Pierre Sicard, Lucas Antônio Miranda Ferreira, Sylvain Richard, Sylvain Richard   +8 more
doaj   +1 more source

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source